电针联合西药治疗化疗所致病理性神经痛的疗效观察

Clinical Observation on Electroacupuncture in the Treatment of Chemotherapy-induced Pathologic Neuropathyic Pain

目的观察电针对化疗药物所致病理性神经痛(CIPN)的治疗效果,为临床上电针治疗化疗药物所致CIPN提供科学依据。方法将28例CIPN病人按随机数字表分为3组。电针组8例,予电针治疗;西药组10例,予甲钴胺片口服治疗;电针联合西药组10例,予电针和口服甲钴胺片联合治疗。3组均治疗1个疗程。采用视觉模拟(VAS)评分评估病人治疗前后疼痛程度,以Likert总体恢复自我评分作为评估病人临床疗效的总体观察指标。结果治疗后3组Likert评分均增高,3组间差异无统计学意义(P>0.05);治疗后电针组和电针联合西药组VAS评分明显低于西药组,差异有统计学意义(P<0.05)。Likert总体恢复自我评分无统计学意义,但具有显著时间效应(P<0.01)。结论电针联合西药治疗可以缓解化疗所致病理性神经痛。

Objective To observe the curative effect on electroacupuncture in the treatment of chemotherapy induced pathologic neu ropathy （CIPN）.Methods Twenty eight patients with CIPN were randomly divided into three groups： group A （n = 8） treated with electroacupuncture,group B （n = 10） treated with mecobalamin tablets, and group C （n = 10） treated with electroacupuncture and mecobalamin tablets for 3 weeks.Before and after treatment, Visual Analogue Scale （VAS） was used to evaluate the curative effect.At the same time,the score of Likert overall self rating was used evaluate the clinical efficacy.Results After the treatment,the scores of Likert overall self rating increased in 3 goups,there was no significant difference among 3 groups （P 〉 0.05）.VAS scores were significantly lower in group A and group C than that in group B （P 〈0.05）.Conclusion The electroacupuncture can alleviate the chemotherapy induced pathologic neuropathy.