间隙连接蛋白43在口腔鳞状细胞癌中的研究进展

Progress in research on connexin 43 in oral squamous cell carcinoma

细胞间隙连接是普遍存在于动物组织中的一种细胞连接形式,介导相邻细胞间的信息、能量和物质的交换。研究表明,间隙连接蛋白43(connexin 43,Cx43)基因的异常表达与肿瘤的发生发展密切相关,本文就Cx43异常表达与口腔鳞状细胞癌的相关研究进展作一综述。

Cell gap junctions are a universal form of cellular connection in animal tissue that mediate the exchangeof information,energy and material between adjacent cells. Clinical studies have demonstrated that the abnormal ex-pression of the connexin 43（Cx43）gene is closely associated with carcinogenesis and tumor progression. The presentstudy reviewed relevant studies concerning the association between abnormal expression of Cx43 and oral squamous cellcarcinoma as well as communication abnormalities of cell gap junctions.