Wnt3a与Wnt5a信号途径转换对造血干细胞衰老的影响

Effects of Wnt3a and Wnt5a signaling pathway switching on hematopoietic stem cells senescence

造血干细胞(HSCs)衰老是机体造血免疫功能衰老的重要原因,在衰老相关疾病的发生中起着关键作用。一定条件下,经典Wnt3a/β-catenin的激活明显有利于保持HSCs的极性与年轻态、自我更新与增殖、分化能力;非经典Wnt5a信号通路的激活则可通过进一步激活细胞内Cdc42蛋白活化等,促发HSCs衰老,并间接抑制Wnt3a/β-catenin通路。对Wnt3a向Wnt5a信号通路转换及其干预的研究不但阐释了HSCs衰老发生的机制,更明确了如何延缓衰老,提供了解决衰老相关疾病及保持年轻态的新策略。

Hematopoietic stem cells（ HSCs） senescence is an important reason of hematopoietical and immunological function senescence. It also is play a key role during aging-related diseases development. Under certain conditions,the activation of classical Wnt3 a/β-catenin is in favour of maintains polarity and young states of HSCs,selfrenewing,proliferation and differentiation potency. Switching to the non-classical Wnt5 a pathway,further activation of Cdc42 protein and others can promote HSCs ageing,and indirectly inhibits Wnt3 a/beta-catenin pathway. The intervention of two Wnt signaling pathways switching and mechanism,not only can illustrate the mechanism of HSCs aging,but also clear how to slow down ageing. This could provide a new strategy on the solution of age-related diseases and keeping a young state.