端粒酶或人端粒酶逆转录酶活性与结直肠癌临床病理特征关系的Meta分析

Relationship of telomerase/human telomerase reverse transcriptase activity with clinicopathological features of colorectal cancer: a Meta-analysis

目的评价端粒酶或人端粒酶逆转录酶(hTERT)活性与结直肠癌患者临床病理特征之间的关系。方法计算机检索PubMed、MEDLINE、EmBase、Web of Science、Cochrane Library、中国期刊全文数据库及万方等数据库,收集关于端粒酶或hTERT活性与结直肠癌患者临床病理特征关系的文献,筛选文献后进行质量评价。采用RevMan 5.0软件进行Meta分析。结果共纳入17篇文献,1 015例结直肠癌患者。Meta分析结果显示,不同肿瘤浸润深度、淋巴结转移、肿瘤远处转移、肿瘤临床分期患者间的端粒酶或hTERT阳性率比较,差异有统计学意义(P<0.05)。结论端粒酶或hTERT过表达可能促进结直肠癌的浸润和转移。

Objective To evaluate the relationship of telomerase/human telomerase reverse transcriptase（hTERT） activity with clinicopathological features in patients with colorectal cancer. Methods A computer retrieval was conducted in the databases,including PubMed,MEDLINE,Em Base,Web of Science,Cochrane Library,China National Knowledge Infrastructure and Wanfang database,to collect the studies on the relationship of telomerase or hTERT activity with clinicopathological features in patients with colorectal cancer. A quality evaluation was carried out following literature screening. Revman 5. 0 software was used for Meta-analysis. Results A total of 17 studies were selected,involving 1015 patients with colorectal cancer. The results of Meta-analysis showed that statistically significant differences were found in the positive rate of telomerase or hTERT among patients with various tumor invasion depths,various lymph node metastasis,various distant metastasis of tumor,or various clinical TNM stages（P〈0. 05）. Conclusion The overexpression of telomerase or hTERT may promote the invasion and metastasis of colorectal cancer.