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局部治疗联合TKI治疗对非小细胞肺癌晚期患者EGFR-TKI治疗后局部进展的效果观察 被引量:1

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摘要 目的分析局部治疗联合酪氨酸激酶抑制剂(TKI)治疗对非小细胞肺癌(NSCLC)晚期患者表皮生长因子受体(EGFR)-TKI治疗后局部进展的效果。方法选择EGFR-TKI治疗后出现局部进展的NSCLC晚期患者64例,对其在继续TKI治疗的前提下进行局部射频消融治疗,观察其近期疗效及远期生存期变化情况。结果治疗1个月后,64例NSCLC晚期患者中,完全缓解17例,部分缓解26例,稳定11例,进展10例,总有效率为67.2%;NSCLC患者初次接受EGFR-TKI治疗时出现局部进展,患者无进展生存期(PFS)为(11.23±5.64)个月,在接受局部治疗联合TKI治疗后,PFS为(21.08±6.29)个月。结论局部治疗联合TKI治疗对NSCLC患者EGFR-TKI治疗后局部进展的治疗效果较好,可延长患者PFS,值得临床推广。
机构地区 嘉兴市第一医院
出处 《现代实用医学》 2018年第4期451-452,562,共3页 Modern Practical Medicine
基金 浙江省卫生厅项目(2014KYB163)
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  • 1马宽生,丁钧,陈敏,欧霞,董家鸿.射频消融治疗549例肝肿瘤的并发症分析[J].第三军医大学学报,2005,27(19):1960-1961. 被引量:14
  • 2Lai EC, Fan ST, Lo CM, et al. Hepatic resection for hepatocellular carcinoma:An audit of 343 patients[J]. Ann Surg, 1995, 221(3):291- 298.
  • 3Lau WY, Leung TW, Yu SC, et al. Percutaneous local ablative therapy for hepatocellular carcinoma: a review and look into the future[J]. Ann Surg, 2003, 237(2): 171 - 179.
  • 4Liang HH, Chen MS, Peng ZW, et al. Percutaneous radiofrequency ablation versus repeat hepatectomy for recurrent hepatocellular carcinoma:a retrospective study[J]. Ann Surg Oncol, 2008, 15(12):3484-3493.
  • 5Rossi S, Di Stasi M, Buscarini E, et al. Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer[J]. AJR, 1996, 167(3):759-768.
  • 6Tateishi R, Shiina S, Teratani T, et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma: An analysis of 1000 cases[J]. Cancer, 2005, 103(6): 1201-1209.
  • 7Kim ES, Hirsh V, Mok T, et al. Gefitinib versus docetaxel in previously treated NSCLC (INTEREST): a randomized phase III trail. Lancet, 2008, 372(9652): 1809-1818.
  • 8Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced NSCLC: results from a randomized, placebo-cotrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet, 2005, 366(9496): 1527-1537.
  • 9Onitsuka T, Uramoto H, Nose N, et al. Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status. Lung Cancer, 2010, 68(2): 198-203.
  • 10Engelman JA, Mukohara T, Zejnullahu K, et al. Allelic dilution obscures detection of a biologically significant resisitance mutation in EGFR-amplified lung cancer. J Clin Invest, 2006 (10): 2695-2706.

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