非编码RNA在舌鳞状细胞癌中的研究进展

Research progress on non-coding RNAs in tongue squamous cell carcinoma

随着整个基因组学和转录组学测序技术的发展,非编码RNA(nc RNA)越来越受到关注。大量研究发现,nc RNA可以通过对染色体重构、转录和转录后翻译等生物学进程来调节基因的表达,并且这些异常表达的nc RNA与人类多种疾病(例如肿瘤)的发生、发展联系十分紧密。nc RNA逐渐成为肿瘤研究中诊断和预后的新型生物学标记和靶向治疗策略。nc RNA在人的舌鳞状细胞癌中也发挥着重要的作用,本文对nc RNA在舌鳞状细胞癌中的研究进展进行综述。

As the development of genomics and transcriptomics, non-coding RNAs （ncRNAs） have been paid much attention. Previous studies have suggested that ncRNAs could regulate gene expression through several biological processes such as chromosome remodeling, transcription, and posttranscription translation. Abnormal versions of ncRNAs are closely related to several human diseases such as file generation and development of tumors. Therefore, ncRNAs may become novel biomarkers in the diagnosis, prognosis and target therapies of tumor research. As file essential role of ncRNAs playing in tongue squamous cell carcinoma （TSCC）, the latest domestic and foreign literatures in TSCC progression were reviewed in this article