影响脑胶质瘤患者生存和预后的相关因素分析

Analysis for related factors influencing the survival and prognosis of patients with brain glioma

目的研究影响脑胶质瘤患者生存和预后的相关因素,为临床治疗提供理论依据。方法回顾性分析2008至2011年收治的脑胶质瘤患者130例,分别考察年龄、病理级别、切除肿瘤、TIP蛋白、TM4SF1蛋白、性别、KPS和病灶数目对脑胶质瘤患者生存中位时间的影响和对脑胶质瘤患者的3年生存率、5年生存率的影响。结果年龄、病理级别、切除肿瘤程度、TIP蛋白、KPS和TM4SF1蛋白均可影响患者的中位生存时间(P<0.05);年龄、病理级别、切除肿瘤程度、肿瘤直径、TIP30蛋白和TM4SF1蛋白均为脑胶质瘤患者的独立危险因素,TIP30蛋白和KPS为保护因素;年龄、病理级别、切除肿瘤程度、KPS、肿瘤直径、TIP蛋白和TM4SF1蛋白均可提高脑胶质瘤患者的3年生存率和5年生存率(P<0.05)。结论年龄、病理级别、切除肿瘤程度、TIP蛋白、KPS和TM4SF1蛋白均可影响患者的生存和预后。临床可针对患者的上述临床指标,建立个体化治疗方案,延长患者的生存时间。

Objective To investigate the related factors influencing the survival and prognosis of patients with brain glioma,and to provide theoretical basis for clinical treatment. Methods The clinical data about 130 patients with brain glioma who were admitted and treated in our hospital from 2008 to 2011 were retrospectively analyzed. The effects of patient＇s age and gender,pathological grade,degree of tumor excision,tip protein,TM4SF1 protein,KPS score and the number of lesions on patient＇s median survival time,3-year survival rate,5-year survival rate were investigated. Results The patient ＇s age,pathological grade,degree of tumor excision,tip protein,TM4SF1 protein,KPS score and TM4SF1 protein could obviously influence patient＇s median survival time（ P 〈0. 05）. Moreover patient＇s age,pathological grade,degree of tumor excision,tumor size,TIP protein,TM4SF1 protein were independent risk factors for patients with brain glioma,however,TIP30 protein and KPS score were protective factors. Furthermore patient＇s age,pathological grade,degree of tumor excision,KPS,tumor size,TIP protein and TM4SF1 protein could affect the 3-year survival rate,5-year survival rate of patients with brain glioma.Conclusion The patient ＇s age,pathological grade,degree of tumor excision,TIP protein,KPS and TM4SF1 protein can influence the survival and prognosis of patients with brain glioma,thus,it is important to establish individualization therapeutic schedule to extend the survival time of patients.