雷替曲塞结合肝动脉化疗栓塞术治疗胃癌术后肝转移的临床研究

Clinical study of raltitrexed combined with hepatic artery chemoembolization in the treatment of liver metastasis of postoperative gastric carcinoma

目的探究雷替曲塞结合肝动脉化疗栓塞术(TACE)治疗胃癌患者术后肝转移的疗效。方法选择2016年1月~2017年5月某院肿瘤科收治的90例胃癌术后肝转移患者,随机分组,对照组给予奥沙利铂+5-氟尿嘧啶肝动脉化疗栓塞;观察组给予雷替曲塞+奥沙利铂肝动脉化疗栓塞,对比两组的治疗效果。结果观察组的治疗有效率62.22%,高于对照组的40.0%,组间差异具有统计学意义(P<0.05);两组的术后不良反应发生率之间对比差异不明显(P>0.05),且多为1~2级,可耐受。结论雷替曲塞结合TACE术治疗胃癌术后肝转移疗效确切,安全性高,利于肿瘤的控制,值得推广。

Objective To investigate the efficacy of raltitrexed combined with hepatic artery chemoembolization in the treatment of liver metastasis of postoperative gastric carcinoma. Methods 90 patients with liver metastasis of postoperative gastric carcinoma selected from hospital between January 2016 and May 2017 Were randomly divided into two groups. The control group gave oxaliplatin ＋ 5-fluorouracil combined with hepatic artery chemoembolization. The observation group was given the treatment of retixic ＋ oxaliplatin and hepatic artery chemoembolization. The therapeutic effects of the two groups were compared. Results The effective rate of the observation group was 62.22%, higher than that of the control group 40%（P〈0.05）. There was no significant difference between the two groups in the incidence of drug adverse reaction, mostly 1-2 grade, tolerable（P〉0.05）. Conclusion The treatment of raltitrexed combined with hepatic artery chemoembolization in the liver metastasis of postoperative gastric carcinoma is effective and safe, which is beneficial to the control of tumor. It is worthy to be popularized.