泮托拉唑预防急性脑梗死并发应激性溃疡有效性和安全性分析

Analysis of the efficacy and safety of pantoprazole in the prevention of acute cerebral infarction with stress ulcer

目的探讨泮托拉唑预防急性脑梗死并发应激性溃疡有效性和安全性。方法急性脑梗死患者126例,随机分成63例观察组和63例对照组。对两组患者均开展常规治疗,观察组在此基础上加用泮托拉唑,分析两组患者临床有效率,对比不良反应发生率。结果观察组63例中,显效28例,有效32例,无效3例,总有效率95.24%;对照组63例中,显效20例,有效22例,无效21例,总有效率66.67%,观察组显著优于对照组,差异有统计学意义(χ~2=8.43,P<0.05)。观察组患者的总体临床症状发生率显著低于对照组(P<0.05),未发生不良反应。结论泮托拉唑预防急性脑梗死并发应激性溃疡有效性和安全性均较高。

Objective To investigate the efficacy and safety of pantoprazole in the prevention of acute cerebral infarction（ACI） with stress ulcer. Methods 126 patients with acute cerebral infarction were randomly divided into 63 observation group and 63 control group. The two groups of patients were treated with conventional treatment. On the basis of the observation group, pantoprazole was used to analyze the incidence of stress ulcer in the two groups,and the clinical efficiency was compared. Results Of the 63 cases of the observation group, 28 cases were shown, 32 cases were effective, 3 cases were invalid and the effective rate was 95.24%. In the control group, 20 cases were markedly effective, 22 cases were effective, 21 cases were invalid, the effective rate was 66.67%, the observation group was significantly better than the control group, with statistical difference（χ^2= 8.43, P〈0.05）. The overall clinical symptom rate of the patients in the observation group was significantly lower than that of the control group（P〈0.05）, and there was no adverse reaction. Conclusion Pantoprazole is effective and safe in the prevention of acute cerebral infarction with stress ulcers.