质子泵抑制剂和H2-受体拮抗剂治疗上消化道出血分析

Proton Pump Inhibitors and H2-receptor Antagonists in the Treatment of Upper Gastrointestinal Bleeding

目的探讨质子泵抑制剂和H2-受体拮抗剂治疗上消化道出血的价值。方法收集我院上消化道出血的患者,出血原因为消化道溃疡造成,随机将患者分为研究组(治疗方案为质子泵抑制剂和H2-受体拮抗剂)和对照组(治疗方案为质子泵抑制剂)。结果研究组和对照组上消化道出血的止血效果分别为100%、90%,组间比较,差异具有统计学意义(P<0.05);研究组和对照组出血停止时间、溃疡愈合时间及住院时间分别为[(2.52±0.34)天、(8.52±1.35)天、(10.52±2.52)天],[(3.36±0.52)天、(10.35±2.67)天、(13.62±3.97)天,组间数据比较,差异具有统计学意义(P<0.05)。结论质子泵抑制剂和H2-受体拮抗剂治疗上消化道出血疗效肯定,能够明显缩短患者出血时间,促进溃疡的愈合。

Objective To investigate the value of proton pump inhibitors and H2-receptor antagonists in the treatment of upper gastrointestinal bleeding. Methods The patients with hemorrhage of upper gastrointestinal tract were collected, the cause of hemorrhage was caused by peptic ulcer, and the patients were randomly divided into the study group（the treatment scheme was proton pump inhibitor and H2-receptor antagonist） and the control group（the treatment is proton pump inhibitor）. Results The hemostatic effects of the study group and the control group were 100% and 90% respectively, and the difference between the two groups was statistically significant（P 〈0.05）. The bleeding stop time, ulcer healing time and hospitalization time of the study group and the control group were [（2.52±0.34） days,（8.52±1.35） days,（10.52±2.52） days], [（3.36±0.52） days,（10.35±2.67） days,（13.62±3.97） days, and the difference between the groups was statistically significant（P〈 0.05）. Conclusion Proton pump inhibitors and H2-receptor antagonists are effective in the treatment of upper gastrointestinal bleeding, which can significantly shorten the bleeding time and promote the healing of ulcers.