BRPF蛋白的生物学功能及其抑制剂研究进展

Research progress on biological function of BRPF proteins and its inhibitors

BRPF(bromodomain and PHD finger containing)蛋白作为表观遗传"reader"结构域,能特异性地识别组蛋白"尾部"乙酰化的赖氨酸残基以促进靶基因的转录。本文综述了BPRF蛋白如何识别和结合乙酰赖氨酸标记,讨论了乙酰化组蛋白识别对其生物学功能的重要性,以及总结了BRPF bromodomain抑制剂的研究进展。

Bromodomain and PHD finger containing（ BRPF） proteins function as epigenetic readers that specifically recognize acetylated lysine on histone tails to facilitate the transcription of target genes. This review summarized our understanding of how BRPF proteins recognize and bind for acetyl-lysine marks,the importance of acetylated histone recognition for their biological functions and the development of inhibitors of BRPF bromodomains.