介孔硅材料提高难溶性药物生物利用度的研究进展

Research progress of mesoporous silicon materials for improving bioavailability of insoluble drugs

介孔二氧化硅作为近年来比较热门的无机介孔载体材料,因其具有孔道排列规整、水热稳定性良好、生物相容性好,可以储存药物并保持药物的无定形态等特点,非常适合装载水难溶性药物。本文通过查阅国内外的相关文献,就难溶性药物口服生物利用度低的原因进行分析,并归纳总结了国内外关于介孔二氧化硅载体提高难溶性药物生物利用度方面的最新研究进展,为设计和制备具有特定结构和性能的介孔二氧化硅载体,提高难溶性药物的生物利用度及其临床应用提供参考。

Mesoporous silica as a popular inorganic mesoporous carrier material recently is suitable for loading insoluble drugs at amorphous state due to its uniform pore,good thermal stability and biocompatibility. The reasons for low oral bioavailability of insoluble drugs were analyzed by reviewing the relevant literature at home and abroad,and the latest research progress of mesoporous silica carrier material for improving bioavailability of insoluble drugs were also concluded. This provided references for design and preparation of mesoporous silica carrier materials with specific structure and characterization for improving bioavailability of insoluble drugs in clinical application.