降钙素原与C反应蛋白联合检测在肝硬化合并肺部感染患者中应用价值

Application of joint detection of procalcitonin and C-reactive protein in patients with liver cirrhosis plus pulmonary infection

目的:探讨降钙素原(PCT)与C反应蛋白(CRP)联合检测在肝硬化合并肺部感染患者中的应用价值。方法:选取某院收治的46例肝硬化合并肺部感染患者为观察组,选取同期入院治疗的46例肝硬化且无肺部及其他部位感染的患者作为对照组。对比2组患者PCT与CRP水平及PCT,CRP检测阳性率;比较2组患者PCT,CRP单独检测及联合检测的准确度、灵敏度、特异度、阳性预测值及阴性预测值。结果:观察组患者PCT及CRP水平均较对照组高,差异有统计学意义(P<0.05);革兰阴性菌组PCT水平较革兰阳性菌组及真菌组高,差异有统计学意义(P<0.05);革兰阳性菌组PCT水平较真菌组高,差异有统计学意义(P<0.05);3组患者CRP水平比较,差异无统计学意义(P>0.05);观察组患者PCT及CRP检测阳性率较对照组高,差异有统计学意义(P<0.05);PCT与CRP联合检测的准确度、灵敏度、特异度、阳性预测值及阴性预测值均较单独检测高,差异有统计学意义(P<0.05)。结论:PCT与CRP联合检测在肝硬化合并肺部感染中有较高的准确度、灵敏度及特异度,对肝硬化肺部感染的早期诊断具有重要的临床参考价值。

Objective： To investigate the application value of joint detection of procalcitonin（ PCT） and C-reactive protein（ CRP）in patients with liver cirrhosis plus pulmonary infection.Methods： 46 patients with liver cirrhosis plus pulmonary infection in a hospital were selected as an observation group,while 46 patients with liver cirrhosis but without pulmonary infection or other infections were selected as a control group. The PCT and CRP levels as well as the positive detection rate of PCT and CRP of the two groups were compared. The accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of single or joint detection of PCT and CRP were compared between the two groups.Results： The PCT and CRP levels of the observation group were higher than those of the control group（ P〈0.05）.The PCT level of gram-negative bacterium group was higher than that of gram-positive bacterium group and fungus group（ P〈0.05）.The PCT level of gram-positive bacterium group was higher than that of fungus group（ P〈0.05）. There was no statistical difference in the CRP levels among the three groups（ P〈0.05）. The positive detection rate of PCT and CRP in the observation group was higher than that in the control group（ P〈0. 05）. The accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of joint detection of PCT and CRP were higher than those of single detection（ P〈0.05）.Conclusion： Joint detection of PCT and CRP in patients with liver cirrhosis plus pulmonary infection has higher accuracy,sensitivity and specificity. It has important significance in early differentiation of liver cirrhosis with pulmonary infection,which can provide basis for clinical treatment.