辛伐他汀相关肝损害6例

Six cases of simvastatin related liver impairment

本文报道了6例与辛伐他汀有关的药品不良反应,这6名患者的平均年龄为57.8岁。在给予辛伐他汀片20 mg口服,每晚1次,平均治疗10 d后出现了不同程度的肝损害。这6份病例中1份病例同时出现转氨酶升高和血清胆红素升高,1份病例同时出现了转氨酶升高和碱性磷酸酶升高,另外4份病例出现了转氨酶升高。在平均给予保肝药物治疗9 d后,4名患者的肝损害均治愈,转氨酶和血清胆红素、碱性磷酸酶均恢复正常水平,1名患者血清胆红素、碱性磷酸酶恢复正常,转氨酶轻微高于正常水平;1名患者血清胆红素、谷丙转氨酶轻微高于正常水平,其余几项转氨酶指标恢复正常。

Six adverse of drug reactions caused by simvastatin were reported. The average age of the six patients was 57.8 years old. Simvastatin was given 20 mg orally, once per night. Various degrees of liver impairment after an average of 10 days treatment occurred： 4 showed an increased in transaminase, 1 showed increased transaminase and increased serum bilirubin, and 1 showed incerased transaminase and alkaline phosphates. After a 9 days treatment on average, the liver impairment of the 4 patients was cured. Both the transaminase and serum bilirubin retured to normal. The serum bilirubin and alkaline phosphates of 1 patient retured to normal, while the transaminase was slightly higher than normal. The than normal in another patients, while transaminase indicators serum bilirubin and the ALT were slightly higher retured to normal.