不同民族的IgA肾病合并高血压患者的临床病理分析

Clinicopathological analysis of IgA nephropathy with hypertension in different ethnic groups

目的探讨不同民族的IgA肾病(IgAN)合并高血压患者的临床和病理特征。方法调取新疆维吾尔自治区人民医院肾病科近5年经肾活检术病理诊断为IgAN患者的资料信息,分别将汉族和维吾尔族患者分为高血压组和非高血压组,进行回顾性分析研究。结果血尿酸、血肌酐、尿蛋白定量及三酰甘油等在族内和(或)族间差异有统计学意义(P<0.05);慢性肾脏病分期及病理改变在汉族的高血压组和非高血压患者间差异有统计学意义(P<0.05);两族的高血压组和非高血压患者间的牛津分级MEST评分差异有统计学意义(P<0.05)。结论 IgAN合并高血压较常见,及时降低血尿酸、血肌酐、尿蛋白及三酰甘油等水平对控制血压极为重要,从而延缓Ig AN进展。

Objective To investigate the clinical and pathological features of IgA nephropathy（ IgAN） in different ethnic groups with hypertension. Methods The data of patients with pathological diagnosis of IgAN by renal biopsy in the Department of Nephrology,Xinjiang Uygur Autonomous Region People＇s Hospital during the recent 5 years were collected for retrospective analysis. The patients of Han and Uygur were further divided into hypertensive group and non-hypertensive group. Results There were significant differences in serum uric acid,serum creatinine,urinary protein and triglyceride,and so on between Han and Uygur populations and between hypertension and non-hypertension groups. There were also significant differences in chronic kidney disease staging and pathological changes between Han hypertension group and non-hypertensive patients. There were significant differences in the Oxford graded MEST score between hypertensive and non-hypertensive groups in both Han and Uighur patients. Conclusion IgAN combined with hypertension is common. The reduction of serum uric acid,serum creatinine,urinary protein and triglyceride levels are extremely important for blood pressure control,thus slowing the progress of IgAN.