摘要
目的对蒙药沙芥(Pugionium cornutum(L.)Gaertn.)中的含氮类成分进行研究,为其资源开发与利用提供依据。方法综合应用大孔吸附树脂、正相硅胶、反相ODS和Sephadex LH-20等柱色谱以及高效液相色谱法对沙芥中含氮类成分进行分离纯化,并结合单体成分的理化性质与核磁共振波谱数据鉴定其结构。结果从沙芥的体积分数70%乙醇提取物中分离鉴定了10个含氮类成分,分别为5-(methylsulfinyl)-pentanenitrile(1)、2-苯乙基芥子油苷(2)、2-phenylethyl-desulphoglucosinolate(3)、N-methoxyl-3-indolymethyldesulphoglucosinolate(4)、arvelexin(5)、cappariloside A(6)、L-色氨酸(7)、L-苯丙氨酸(8)、3-phenylpropanamide(9)、腺苷(10)。结论在对沙芥化学成分的研究过程中,分离鉴定了10个含氮类单体成分。其中,化合物1~7、9、10为首次从该属植物中分离得到,并首次报道了化合物2的核磁共振波谱数据。
As one kind of the traditional food for Mongolian people for thousands of years, Pugionium cornutum L. Gaertn, exhibits the bioactivity to promote digestion. Meanwhile, as the barier of wind and sand, P. cornutum has drawn more and more attention of the researchers around the world. While there hasn't been enough studies about it. With the help of multiple chromatographic and spectroscopic methods, ten compounds containing nitrogen atoms in their chemical structures, 5- ( methylsulfinyl ) -pentanenitrile ( 1 ), phenylethyl glucosinolate ( 2 ), 2-phenylethyl-desulphoglucosinolate ( 3 ), N-methoxyl-3-indolymethyldesul phoglucosinolate ( 4 ), arvelexin ( 5 ), cappariloside A ( 6 ), L-tryptophan ( 7 ), L-phenylalanine ( 8 ), 3-phenyl propananaide (9), adenosine ( 10 ) were isolated and identified. Among them, compounds 1 - 7,9,10 were obtained from Pugionium genus firstly, and the NMR data of 2 was reported for the first time.
作者
黄培建
史文中
瞿璐
郑畅
王涛
张祎
HUANG Pei-jian;SHI Wen-zhong;QU Lu;ZHENG Chang;WANG Tao;ZHANG Yi(Tianijin University of Traditional Chinese Medicine,Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin,Tianjin 300193,China)
出处
《中国药物化学杂志》
CAS
CSCD
北大核心
2018年第4期318-322,共5页
Chinese Journal of Medicinal Chemistry
基金
国家自然科学基金面上项目(81673688)
关键词
蒙药
沙芥
化学成分
含氮类成分
结构鉴定
Traditional Mongolian Medicine
Pugionium cornutum (L.) Gaertn.
chemical constituents
compounds containing nitrogen atoms
structural identification