蒙古族人群脑梗死患者急性期血清同型半胱氨酸水平变化研究

Serum homocysteine level in Mongolian acute cerebral infarction population

目的探讨蒙古族人群患脑梗死与血清同型半胱氨酸(Hcy)的相关性。方法选择蒙古族脑梗死患者73例(发病<7d)为病例组及蒙古族健康体检者80例为对照组,入选者均为3代以上蒙古族。检查2组血清Hcy、叶酸、维生素B_(12)及LDL水平,进行相关分析和多元逐步logistic回归分析。结果病例组Hcy[(21.34±16.51)μmol/L vs(13.78±5.78)μmol/L,P<0.01]明显高于对照组;血清Hcy与叶酸、维生素B_(12)水平呈负相关(P<0.01)。高血压、糖尿病及吸烟是患者影响因素(P<0.05);血清Hcy水平升高是蒙古族脑梗死的独立危险因素(OR=3.88,95%CI:2.43~11.27,P=0.006)。结论血清Hcy是蒙古族脑梗死的重要危险因素。

Objective To study the association between cerebral infarction（CI）and serum homocysteine（Hcy）level in Mongolian population.Methods Seventy-three Mongolian CI patients served as a CI group and 80 healthy Mongolian persons undergoing physical examination served as a control group in this study.Their serum Hcy,folic acid（FA）,vitamin B_（12） and LDL levels were measured and analyzed by correlation analysis and multivariate stepwise logistic regression analysis respectively.Results The serum Hcy levels were significantly higher in CI group than in control group（21.34±16.51μmol/Lvs 13.78±5.78μmol/L,P〈0.01）.The incidence of hypertension and diabetes was significantly higher,the history of smoking was significantly longer in CI group than in control group（P〈0.05）.The serum level of Hcy was negatively associated with that of FA and vitamin B_（12）（P〈0.01）.Elevated serum Hcy level was an independent risk factor for CI in Mongolian population（OR=3.88,95%CI：2.43-11.27,P=0.006）.Conclusion Serum Hcy level is an important risk factor for CI in Mongolian population.