肝炎病毒感染与胃肿瘤发生的相关性研究

Study on correlation between infection of hepatitis virus and occurrence of gastric tumors

目的探讨乙型肝炎病毒(HBV)及丙型肝炎病毒(HCV)与胃部肿瘤发生的相关性。方法以肝癌为阳性对照,以全国和广东地区的HBV、HCV感染率为基础计算期望值,回顾性分析南方医院2007-2016年胃肿瘤患者中HBV及HCV的感染情况,分别计算HBV、HCV在不同年龄段、不同地区、不同病理分期的观察值及标准化发病率(SIR)及SIR精确(泊松分布)的95%置信区间,分析HBV、HCV感染与胃肿瘤发生的相关性。结果 HBV和胃癌的SIR有统计学差异,且与发病年龄、发病地区及不同类型、低中分化的胃癌均相关,而HBV与高分化胃癌无统计学差异。HBV与胃间质瘤的SIR具有统计学差异,与胃类癌的SIR则无。而HCV与胃癌的SIR无统计学差异。结论 HBV与胃癌、胃间质瘤的发生具有相关性,其可能是胃癌发生、发展的一个危险因素。

Objective To explore the correlation between the infection of hepatitis B virus（HBV）and hepatitis C virus（HCV）with the occurrence of gastric tumors.Methods With liver cancer as the positive control,the expectation value was calculated on the base of the infection rate of HBV and HCV in the whole country and Guangdong area.The infection situation of HBV and HCV in the patients with gastric tumors in Nanfang Hospital during 2007？2016 were retrospectively analyzed.The observation values,standardized incidence ratios（SIR）and SIR precision（Poisson distribution）95% confidence interval of HBV and HIV in different age groups,different areas and different pathological stages were calculated respectively.The correlation between the infection of HBV and HCV with gastric tumor occurrence was analyzed.Results SIR had statistical difference between HBV with gastric cancer;HBV had correlated with the onset age,onset area,different types and low-middle differentiation,while HBV had no statistical difference with high differentiation gastric cancer.HBV had statistical difference with SIR of gastric stromal tumor,while had no statistical difference with SIR of gastric carcinoid.HCV had no statistical difference with SIR of gastric cancer.Conclusion HBV has a correlation with gastric cancer and gastric stromal tumor,which may a risk factor for the occurrence and development of gastric tumors.