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CD146 is essential for PDGFRβ-induced pericyte recruitment 被引量:10

CD146 is essential for PDGFRβ-induced pericyte recruitment
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摘要 Dear Editor, The homeostasis of the central nervous system (CNS) is regulated through the blood-brain barrier (BBB), a protective barrier between the peripheral blood and the brain (Zhao et al., 2015). As vascular mural cells of brain microvessels, pericytes are positioned within the neurovascular unit among endothelial cells (ECs), astrocytes, and neurons. During the embryogenesis, pericytes are recruited to and interacts with the nascent CNS vascular ECs for BBB formation and maturation. Dear Editor, The homeostasis of the central nervous system (CNS) is regulated through the blood-brain barrier (BBB), a protective barrier between the peripheral blood and the brain (Zhao et al., 2015). As vascular mural cells of brain microvessels, pericytes are positioned within the neurovascular unit among endothelial cells (ECs), astrocytes, and neurons. During the embryogenesis, pericytes are recruited to and interacts with the nascent CNS vascular ECs for BBB formation and maturation.
出处 《Protein & Cell》 SCIE CAS CSCD 2018年第8期743-747,共5页 蛋白质与细胞(英文版)
基金 This work was supported by the National Basic Research Program of China (973 Programs, 2015CB553705, 2014CBA02003), the National Natural Science Foundation of China (Grant Nos. 31370824, 31771628, 81371025, 91529306, 81371330, 91640112, 31670185, 81527805, 81671851, and 81502547), Guangdong Natural Science Fund for Distinguished Young Scholars (2017A030306024), and China and Novo Nordisk-CAS Research Fund (NNCAS-2015-11 ).
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