脓毒症线粒体功能障碍及复苏

Mitochondrial dysfunction and resuscitation in sepsis

鉴于脓毒症的组织病理变化与严重器官功能障碍不一致，亟待探索炎症与免疫之外的脓毒症发病机制。线粒体功能障碍为脓毒症器官功能障碍的发生予以不寻常的解释，虽未证明其间确切的因果关系，但建议通过改善线粒体代谢，促进脓毒症器官功能恢复。本文将从线粒体生物学、脓毒症线粒体功能障碍、脓毒症代谢失调和线粒体复苏等方面进行阐述。

Considering that the pathological changes are inconsistent with severe organ dysfunction of sepsis. It is urgent to explore the other pathogenetic mechanisms besides inflammation and immunity. A extraordinary explanation for multiple organ dysfunction is associated with mitochondrial dysfunction during sepsis. Although the exact relationship between them is not proved, and therapeutic strategy is suggested to promote the organs function by improving mitochondrial metabolism for sepsis. This article focused on mitochondrial biology, mitochondrial dysfunction, metabolic disorder and mitochondrial resuscitation in sepsis.