某三甲医院门诊处方超说明书用药分析

Analysis of Off-label Use in Grade-A Tertiary Hospital

目的调查分析医院门诊处方超说明书用药情况。方法筛选2016年某院门诊处方2 250张,调查并分析本组门诊处方的超说明书用药率、用药类型、涉及科室及用药种类。结果 2 250张门诊处方中共包含7 500条用药记录,其中超说明书用药处方为230张(10.22%),超说明书用药记录为325条(4.33%)。超给药剂量的发生率明显高于超给药频次、超适应证、超年龄、超疗程、超溶媒的发生率,差异有统计学意义(P<0.01)。本组门诊处方超说明书用药的前3位药物种类为甲氨蝶呤片36张(15.65%)、阿司匹林肠溶片24张(10.43%)、泮托拉唑肠溶胶囊23张(10.00%)。结论超说明书用药十分普遍,且具有一定的风险,所以应尽早完善相关规定与制度,保证患者的用药质量。

OBJECTIVE To investigate and analyze the drug use of out-patient prescriptions in the hospital. METHODS 2 250 outpatient prescriptions in our hospital in 2016 were selected,investigated and analyzed the out label drug use rate,drug types,related departments and drug types of outpatient prescriptions. RESULTS The 2 250 outpatient prescriptions in this group included 7 500 records of drug use,of which 230（ 10.22%） were used for super instruction.325（ 4.33%） cases of super instructions were recorded. The rate of super dose in this group was significantly higher than the frequency of super administration,super adaptation,super age,super course,and the incidence of super solvent（ P 0. 01）. The top three drugs for outpatient prescriptions were Methotrexate Tablets（ 15.65%）,Aspirin Enteric-coated Tablets（ 10. 43%）,and pantoprazole enteric coated capsules（ 10%）. CONCLUSION Super instruction is very common and has a certain risk. so,the relevant regulations and systems should be perfected as soon as possible to guarantee the quality of the patients medication.