银杏达莫注射液联合生长抑素治疗急性胰腺炎的临床研究

Clinical study of Ginkgo Leaf Extract and Dipyridamole Injection combined with somatostatin in treatment of acute pancreatitis

目的探讨银杏达莫注射液联合生长抑素治疗急性胰腺炎的临床效果。方法选取2015年1月—2017年12月亳州市人民医院收治的82例急性胰腺炎患者,随机分为对照组和治疗组,每组各41例。对照组持续微量泵入注射用生长抑素,以100μg为首次剂量,静脉推注,而后采取静脉微量泵以50μg/h维持。治疗组在对照组治疗基础上静脉滴注银杏达莫注射液,20 mL加入500mL生理盐水均匀混合后给药,1次/d。两组均连续治疗7 d。观察两组的临床疗效,比较两组血、尿淀粉酶(AMY)和血C反应蛋白(CRP)恢复正常时间及腹痛、腹部压痛消失时间。比较两组血AMY、尿AMY活性、血小板平均体积(MPV)、C反应蛋白(CRP)血清水平和改良CT严重指数(MCTSI)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为75.6%、92.7%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组血AMY、尿AMY及血CRP恢复正常时间,腹痛、腹部压痛消失时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血AMY、尿AMY、MPV、CRP水平及MCTSI评分均较治疗前显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组血AMY、尿AMY、MPV、CRP水平及MCTSI评分均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论银杏达莫注射液联合生长抑素治疗急性胰腺炎具有较好的临床疗效,能有效缓解患者症状,改善血小板功能,减轻组织损伤,具有一定的临床推广应用价值。

Objective To investigate the clinical effects of Ginkgo Leaf Extract and Dipyridamole Injection combined with somatostatin in treatment of acute pancreatitis. Methods Patients（82 cases） with acute pancreatitis in the People＇s Hospital of Bozhou from January 2015 to December 2017 were randomly divided into control（41 cases） and treatment（41 cases） groups. Patients in the control group were continuously pumped with Somatostatin for injection, the first dosage was 100 μg for intravenous infusion, and then the intravenous micropump was 50 μg/h. Patients in the treatment group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of the control group, 20 mL added to 500 mL normal saline and fully diluted, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and restored to normal time of blood, urine AMY and blood CRP and disappeared time of abdominal pain and abdominal tenderness in two groups were compared. The changes of blood AMY, urinary AMY, MPV, serum CRP and MCTSI in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 75.6% and 92.7%, and there were differences between two groups（P〈0.05）. After treatment, restored to normal time of blood, urine AMY and blood CRP and disappeared time of abdominal pain and abdominal tenderness in the treatment group were shorter than those in the control group, and there were differences between two groups（P〈0.05）. After treatment, blood AMY, urinary AMY, MPV, serum CRP and MCTSI in the two groups were significantly decreased, and there were differences in the same group（P〈0.05）. After treatment, blood AMY, urinary AMY, MPV, serum CRP and MCTSI in the treatment group were lower than those in the control group, and there were differences between two groups（P〈0.05）. Conclusion Ginkgo Leaf Extract and Dipyridamole Injection combined with somatostatin has significant clinical effect in treatment of acute pancreatitis, and can effectively alleviate symptoms, also can improve platelet function and reduce tissue damage, which has a certain clinical application value.