摘要
目的探讨红金消结片联合醋酸戈舍瑞林缓释植入剂治疗子宫肌瘤的临床疗效。方法选取2016年7月—2017年12月成都中医药大学附属医院妇科收治的子宫肌瘤患者74例为研究对象,采用随机数字表法分为对照组和治疗组,每组各37例。对照组在月经周期第1~7天内经腹部前壁皮下注射醋酸戈舍瑞林缓释植入剂,3.6 mg/次,每隔28天注射1次。治疗组在对照组治疗的基础上口服红金消结片,4片/次,2次/d。两组患者均连续治疗3个月。观察两组的疗效,比较两组的血液流变学指标、性激素水平、子宫体积和子宫肌瘤体积。结果治疗后,对照组和治疗组的总有效率分别为78.38%、94.59%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血浆比黏度、纤维蛋白原、红细胞聚集指数明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血液流变学指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清LH、FSH、P、E_2水平明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组性激素水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组子宫体积和子宫肌瘤体积明显减小,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显小于对照组,两组比较差异具有统计学意义(P<0.05)。结论红金消结片联合醋酸戈舍瑞林缓释植入剂治疗子宫肌瘤具有较好的临床疗效,可改善患者血液流变学,调节性激素水平,缩小患者子宫体积和子宫肌瘤体积,安全性较好,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Hongjin Xiaojie Tablets combined with Goserelin Acetate Sustained-Release Depot in treatment of uterine leiomyoma. Methods Patients(74 cases) with uterine leiomyoma in Teaching Hospital of Chengdu University of Traditional Chinese Medicine from July 2016 to December 2017 were randomly divided into control and treatment groups, and each group had 37 cases. Patients in the control group were sc administered with Goserelin Acetate Sustained-Release Depot through the anterior wall of the abdomen in the period of first to 7 d of the menstrual cycle, 3.6 mg/time, once every 28 days. Patients in the treatment group were po administered with Hongjin Xiaojie Tablets on the basis of the control group, 4 tablets/time, twice daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and hemorheological indexes, sex hormone levels, uterine volume, and uterine leiomyoma volume in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.38% and 94.59%, respectively, and there was difference between two groups(P〈0.05). After treatment, plasma viscosity, fibrinogen, and erythrocyte aggregation index in two groups were significantly decreased, and the difference was statistically significant in the same group(P〈0.05). And the hemorheological indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P〈0.05). After treatment, the levels of LH, FSH, P, and E_2 in two groups were significantly decreased, and the difference was statistically significant in the same group(P〈0.05). And the sex hormone levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P〈0.05). After treatment, uterine volume and uterine leiomyoma volume in two groups were significantly decreased, and the difference was statistically significant in the same group(P〈0.05). And the observational indexes in the treatment group were significantly smaller than those in the control group, with significant difference between two groups(P〈0.05). Conclusion Hongjin Xiaojie Tablets combined with Goserelin Acetate Sustained-Release Depot has clinical curative effect in treatment of uterine leiomyoma, can improve hemorheology, regulate sex hormone levels, reduce uterine volume and uterine fibroid volume, with good safety, which has a certain clinical application value.
作者
任爱玲
REN Ai-ling(Department of Gynecology,Teaching Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《现代药物与临床》
CAS
2018年第7期1771-1774,共4页
Drugs & Clinic
关键词
红金消结片
醋酸戈舍瑞林缓释植入剂
子宫肌瘤
血液流变学指标
性激素水平
子宫体积
子宫肌瘤体积
Hongjin Xiaojie Tablets
Goserelin Acetate Sustained-Release Depot
uterine leiomyoma
hemorheological index
sexhormone level
uterine volume
uterine leiomyoma volume