酒客乐联合泮托拉唑治疗酒精性胃黏膜损伤的临床疗效观察

Clinical efficacy observation of Jiukele combined with Pantoprazole in treating alcoholic gastric mucosal injury

[目的]观察自拟方酒客乐联合泮托拉唑治疗酒精性胃黏膜损伤的临床疗效及胃黏膜修复情况。[方法]抽取我院甘爱萍教授脾胃病科专家门诊2016年11月~2017年11月间接诊的62例患者,参考中西医诊断标准,按随机数字表法分成治疗组和对照组各31例,对照组患者口服40mg/d泮立苏,治疗组酒客乐联合40mg/d泮立苏,联合组和单纯西药组的患者均连续服用4周。观察患者胃痛等临床症状缓解程度、主症胃痛消失时间等情况。[结果]治疗后,联合组中医证候积分明显少于对照组,胃痛程度积分小于对照组,且胃痛消失时间积分优于单纯西药组。差异均有统计学意义。[结论]酒客乐联合泮托拉唑治疗酒精性胃黏膜病变而引发的胃炎或溃疡,可迅速改善胃黏膜损伤,加快胃黏膜修复愈合,临床疗效显著。

[Objective]To observe the clinical efficacy of Jiukele combined with pantoprazole in the treatment of alcoholic gastric mucosal injury and the gastric mucosal healing status.[Methods]62 patients who visited gastroenterology clinic of Professor Gan Aiping in our hospital from November 2016 to November2017 were selected and divided into two groups according to the diagnostic criteria of Chinese and Western medicines.The patients were divided into treatment group（31 cases）and control group（31 cases）by random number table.Patients in the control group were given Pantoprazole（40 mg daily）,while those in the treatment group were given Jiukele combined with Pantoprazole（40 mg daily）.The patients in the combination group and the western medicine group were treated for 4 weeks continuously.To observe the improvement of clinical symptoms,disappearance time of stomachache,etc.[Results]After treatment,the scores of TCM syndromes in the combination group were significantly less than those in the control group and the scores of stomach pain were less than those in the contral group.And the scores of disappearance time of stomach pain were better than that of the western medicine group.The differences were statistically significant.[Conclusion]The combination of Jiukele and pantoprazole in the treatment of gastritis or ulcers caused by alcoholic gastric mucosal lesions can rapidly improve gastric mucosal injury and accelerate the healing of gastric mucosa.The clinical curative effect is remarkable.