MUC1、FAT4、EGFR在食管癌中的表达变化及临床意义

Expression and clinical significance of MUC1,FAT4 and EGFR in patients with esophageal cancer

[目的]比较食管癌患者食管黏膜组织黏蛋白1(MUC1)、钙黏蛋白FAT4和表皮生长因子受体(EGFR)表达水平,并探讨其联合检测的临床意义。[方法]选择院2015年12月至~2017年10月收治的70例食管癌患者为研究对象,并选择同期30例健康患者为对照,采用免疫组化方法检测组织MUC1、FAT4、EGFR的表达,并分析其临床意义。[结果]研究组患者MUC1、EGFR表达阳性率显著高于对照组,FAT4表达阳性率显著低于对照组,差异均有统计学意义(P<0.05);FAT4表达阳性率与MUC1、EGFR负相关(r=-0.683,-0.714),MUC1表达阳性率与EGFR正相关(r=0.806),差异均有统计学意义(P<0.05)。MUC1、FAT4、EGFR表达阳性率与淋巴结转移、肿瘤分期密切相关,差异均有统计学意义(P<0.05)。[结论]食管癌患者食管黏膜组织MUC1、EGFR表达阳性率升高,FAT4表达阳性率降低,MUC1、FAT4、EGFR表达密切相关,与肿瘤转移、侵袭相关,可作为食管癌的诊断标志物。

[Objective]To compare the expression of esophageal mucosa of mucin1（MUC1）,calcium mucins FAT4（FAT4）and epidermal growth factor receptor（EGFR）in patients with esophageal cancer,and investigate the significance of joint detection.[Methods]Seventy patients with esophageal cancer between December 2015 and October 2017 were selected as the research object,and thirty patients with healthy controls in the same period were selected as the control object.The expression of MUC1,FAT4 and EGFR were detected by using immunohistochemical method,and its clinical significance were analyzed.[Results]The expression positive rate of MUC1 and EGFR in research group were significantly higher than the control group,and the expression positive rate of FAT4 was significantly lower than the control group,the differences were statistical significant（P0.05）.The expression positive rate of FAT4 was negative correlation to MUC1 and EGFR（r=0.683,0.683）,the expression positive rate of MUC1 was positive correlation to EGFR（r=0.806）,the differences were statistical significant（P0.05）.The expression positive rate of MUC1,FAT4 and EGFR were closely associated with lymph node metastasis and tumor stage,the differences were statistical significant（P0.05）.[Conclusion]The expression positive rate of MUC1 and EGFR increased in patients with esophageal cancer,and FAT4 decreased.The expression of MUC1,FAT4 and EGFR are closely related,and associated with tumor metastasis.They can be used as the diagnosis markers.