横纹肌肉瘤临床病理分析

Clinicopathological analysis of rhabdomyosarcoma

目的:探讨横纹肌肉瘤(rhabdomyosarcoma,RMS)临床特点、病理形态及免疫表型。方法:回顾性分析39例RMS的临床资料、组织学形态、免疫组织化学。结果:39例RMS中,胚胎性RMS 24例,腺泡状RMS 11例,多形性RMS 3例,梭形/硬化性RMS 1例,多见于青少年,好发于头颈部。31例Desmin(+),32例Myo D1(+),15例Myogenin(+),3例因形态典型,未行免疫组织化学检查。结论:R MS是一种好发于青少年的高度恶性肿瘤。组织学形态上表现为原始的小圆细胞及不同比例的横纹肌母细胞,免疫组织化学表达Desmin,Myo D1和myogenin。

Objective： To explore clinical features, pathological morphology, immunohistochemistry of rhabdomyosarcoma（RMS）. Methods： The clinical characteristics, histological morphology and immune phenotype of 39 cases of RMS were retrospectively analyzed. Results： The 39 cases of RMS involved 24 cases of embryonal RMS（ERMS）, 11 cases of alveolar RMS（ARMS）, 3 cases of pleomorphic RMS（PRMS）, and 1 case of spindle/sclerosing RMS（SRMS）. The diseased region was in head and neck and more likely in teenagers. Immunohistochemical methods showed positive staining for Desmin in 31 cases, positive staining for Myo D1 in 32 cases, and also positive staining for Myogenin in 15 cases. Three of these cases did not performed immunohistochemistry due to the typical morphology. Conclusion： RMS is a kind of high malignant tumor which frequently arose in teenagers. The histomorphology shows the original small round cells and different proportions of rhabdomyoblasts, while immunohistochemistry shows that Desmin, Myo D1 and myogenin are expressed.