多系统萎缩的诊断和治疗的临床研究进展

Clinical research progress in the diagnosis and treatment of multiple system atrophy

多系统萎缩(MSA)是一种中老年起病、进行性发展的神经系统变性疾病,其进展快、预后差。MSA临床表现多样,主要为不典型的自主神经功能障碍和/(或)睡眠障碍,以及运动症状。结合神经影像学、自主神经功能试验等检查有助于早期识别MSA与其他神经系统变性疾病。MSA目前尚无特效疗法,适当的药物和理疗可改善患者的生活质量。本文综述MSA的临床诊断和治疗的相关临床研究。

Multiple system atrophy（MSA） is a neurodegenerative disease with onset and progressive development in the middle and old age, which has rapid progress and poor prognosis. MSA has various clinical manifestations, mainly atypical autonomic dysfunction or sleep disorders, and motor symptoms. Generally, the early identification of MSA and other neurodegenerative diseases can be performed through the combination of neuroimaging with autonomic nerve function tests. At present, the MSA has no specific treatment. However, some medication and physiotherapy can improve the life quality of patients. This article reviews the clinical diagnosis and treatment of MSA.