路易体相关痴呆的诊断与治疗进展

Advances of diagnosis and pharmacotherapy in Lewy body dementias

路易体相关痴呆主要包括路易体痴呆(DLB)和帕金森病痴呆(PDD),两者在神经病理学基础及临床表现方面有相当多的重叠,目前仍主要依据痴呆与运动症状出现的先后顺序进行区分,认知功能障碍发生于帕金森综合征运动症状之前的为DLB,发生于之后的为PDD,对此分类尚有许多争议。本文对DLB与PDD的关系、神经病理学、临床诊断标准以及药物治疗等多方面的进展进行综述。

Dementia syndromes associated with Lewy body are subdivided into dementia with Lewy body（DLB） and Parkinson＇s disease dementia（PDD）. Despite considerable neuropathological and clinical overlap, their diagnosis is based on the onset time of motor and cognitive symptoms. Generally, the dementia onset is preceding parkinsonism called as DLB, and the onset of cognitive impairment is after the onset of motor symptoms called as PDD, and there are still a lot of controversies about the nosology and pathogenesis of both syndromes. This article describes the clinical research progress of both DLB and PDD based on the clinical criteria, neuropathology and pharmacotherapy.