原子吸收光谱法测定果糖二磷酸钠制剂中的铝离子含量

Determination of Al in Fructose Sodium Diphosphate for Injection by Atomic Absorption Spectrometry

目的采用原子吸收光谱法测定国家评价性抽样118批注射用果糖二磷酸钠及果糖二磷酸钠注射液中铝的含量。方法采用硝酸镁作为基体改进剂,塞曼偏振背景校正的原子吸收光谱法测定果糖二磷酸钠制剂中铝的含量。结果铝离子在5~30 ng·m L-1内线性关系良好,相关系数为0.998 5,平均回收率为100.1%,RSD为6.7%(n=9)。结论本方法灵敏、准确,可用于果糖二磷酸钠制剂中铝含量的测定。国内果糖二磷酸钠制剂中铝含量测定结果差异大,产品存在铝含量过高的问题。

OBJECTIVE To establish a graphite furnace atomic absorption spectrometry method for determination of Al in 118 batchs of Fructose Sodium Diphosphate injection and injection for Fructose Sodium Diphosphate for national evalution sampling. METHODS Magnesium nitrate was adopted as matrix modifier, and the content of Al in fructose sodium diphosphate was determined by atomic absorption spectrometry with polarized Zeeman background correction. RESULTSThere was a good linear relationship in the concentration range of 5-30 ng·mL^-1（r=0.998 5）. The average recovery rate was 100.1%, RSD was 6.7%（n=9）. CONCLUSION The method is sensitive and accurate, suitable for determination of Al in Fructose Sodium Diphosphate injection and Injection for Fructose Sodium Diphosphate. The result indicates some of the products vary greatly in Al assay, and the product has high aluminum content.