辛伐他汀联合地尔硫卓治疗糖尿病肾病的疗效及其对蛋白尿的影响

Effect of Simvastatin Combined with Diltiazem on Diabetic Nephropathy and Its Influence on Proteinuria

目的探讨辛伐他汀联合地尔硫卓治疗糖尿病肾病的临床疗效及其对蛋白尿的影响。方法选取128例糖尿病肾病患者作为研究对象,将其随机均分为观察组和对照组,对照组64例在饮食控制以及锻炼的基础上使用辛伐他汀进行治疗,观察组64例在饮食控制以及锻炼基础上使用辛伐他汀联合地尔硫卓进行治疗。结果治疗后2组患者的病情均有所好转,且观察组患者通过治疗后,空腹血糖、餐后2 h血糖、糖化血红蛋白、UAER、UACR显著优于对照组患者,差异有统计学意义(P<0.05);2组患者治疗后24 h蛋白尿定量比较差异有统计学意义(P<0.05)。结论辛伐他汀联合地尔硫卓治疗糖尿病肾病患者的临床疗效好,可延缓疾病进展,提高患者生活质量。

OBJECTIVE To investigate the clinical efficacy and proteinuria of simvastatin combined with diltiazem in the treatment of diabetic nephropathy patients. METHODS One hundred and twenty-eight cases of diabetic nephropathy patients, were divided into observation group and control group randomly. The control group were treated with diet, exercise and simvastatin, while the observed group treated with diet, exercise, simvastatin combined with diltiazem. RESULTS After the treatment, condition of two groups were improved significantly, and the level of blood glucose, fasting blood glucose, postprandial 2 H blood glucose, Glomerular filtration rate, proteinuria changes in the observation group were significantly better than the control group（P〈0.05）. CONCLUSION After diabetic nephropathy patients treated with simvastatin combined with diltiazem, it can improve patients＇ quality of life and have good application value in the treatment of such patients.