振幅整合脑电图联合C-反应蛋白水平在早产儿脑损伤早期诊断中的意义

Application of amplitude integrated electroencephalogram combined with C-reactive protein level in early diagnosis of premature brain injury

目的:探讨振幅整合脑电图联合C-反应蛋白水平在早产儿脑损伤早期诊断中的实际应用效果。方法:选择我院具有高风险脑损伤的早产儿90例,均进行振幅整合脑电图监测及C-反应蛋白水平监测,并根据磁共振成像分成脑损伤组(52例)及非脑损伤组(38例)。统计并分析振幅整合脑电图、C-反应蛋白及两者联用在早产儿脑损伤早期诊断中的灵敏度及特异度。结果:振幅整合脑电图、C-反应蛋白及两者联用在早产儿脑损伤早期诊断中的灵敏度分别为82.69%、71.15%、92.30%,特异度分别为73.28%、84.21%、68.42%。两者联用可以显著增加灵敏度(P<0.05),且ROC曲线下面积最大,为0.804。结论:C-反应蛋白水平的监测可以作为振幅整合脑电图监测早产儿早期脑损伤的补充,两者的联合可以明显提高诊断效能。

Objective： To explore the application of amplitude integrated electroencephalogram （aEEG） combined with C- reactive protein （CRP） level in early diagnosis of premature brain injury. Methods： 90 cases of preterm infants with high risk of brain injury were selected to monitor the aEEG and the level of CRP. According to magnetic resonance imaging （MRI）, they were divided into brain injury group （52 cases） and non brain injury group （38 cases）. The sensitivity and specificity of aEEG and CRP level in early diagnosis of premature brain injury were analyzed. Results： In early diagnosis of premature brain injury, the sensitivity was 82. 69%, 71.15% , 92.30% , and the specificity was 73.28% , 84.21% , 68.42% for aEEG alone, CRP level alone and combined use of both. The combined use of aEEG and CRP level to diagnose brain injury in premature infants could significantly increase the sensitivity （P 〈 0.05） , and the area under the ROC curve was the maximum, it was 0. 804. Conclusion： The monitoring of CRP level can be used as a supplementary technology for monitoring the brain damage of premature infants in early diagnosis by aEEG, which could improve the actual diagnosis effect.