瘢痕疙瘩发生和发展的整体观机制探讨

Integrative Mechanism for Keloid Origination and Development

瘢痕疙瘩被定义为一种皮肤组织的局部纤维化疾病,而以往相关的研究也多局限在瘢痕疙瘩细胞本身。然而,瘢痕疙瘩只在人体中形成,缺乏可靠的动物模型,并且病变局部治疗后仍具有高复发率和难以治愈的特点,提示需要重新审视传统的研究策略。本述评基于瘢痕疙瘩临床表现和文献研究结果,提出需要开展瘢痕疙瘩发生与发展的整体观机制探讨,并将对该疾病的认识扩展到系统性疾病在皮肤的表现。同时,认为相关研究策略需要从病变局部研究过渡到系统因素研究,以及系统因素与局部因素相互作用的领域,为瘢痕疙瘩全身性治疗提供相关科学依据。

Keloid is usually defined as a localized fibrotic disease limited to human skin in the medical field and the past research literatures also focused on keloid cells. However, keloid only forms in human being and lacks proper animal models. In addition, keloid is difficult to heal with high rate of recurrence. These characteristics suggest that the current strategy of keloid research is needed to change. Based on clinical manifestation and literature reports, this expert eonunent proposes that an integrative strategy- should be adapted to investigate the mechanism of keloid origination and development, and keloid might be a systemic disease with its manifestation at human skin. Meanwhile, future keloid research should also been evolved from abnormality of local skin tissue to the contribution of systemic factors and the interaction between systemic factors and local skin cells.