胺碘酮联合美托洛尔治疗老年冠心病并发心律失常的疗效研究

Effect research of Amiodarone combined with Metoprolol in the treatment of elderly patients with coronary heart disease complicated with arrhythmia

目的探究胺碘酮联合美托洛尔治疗老年冠心病并发心律失常的疗效。方法 86例老年冠心病并发心律失常患者,随机分为对照组和实验组,各43例。对照组采用胺碘酮治疗,实验组采用胺碘酮联合美托洛尔治疗,对比两组治疗效果。结果实验组治疗总有效率为93.0%,对照组治疗总有效率为76.7%;实验组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组QT间期离散度(QTd)与心率均低于治疗前,且实验组QTd与心率明显低于对照组,差异均有统计学意义(P<0.05)。实验组不良反应发生率为9.3%,对照组不良反应发生率为27.9%;实验组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论老年冠心病并发心律失常患者采用胺碘酮联合美托洛尔治疗,可以取得理想的治疗效果,且不良反应少,具有较高的安全性与可靠性,能够对患者的症状进行显著改善,对心率进行合理控制,在临床上值得推广使用。

Objective To investigate the effect of Amiodarone combined with Metoprolol in the treatment of elderly patients with coronary heart disease complicated with arrhythmia. Methods A total of 86 elderly patients with coronary heart disease complicated with arrhythmia were randomly divided into control group and experimental group, 43 cases in each group. The control group was treated with Amiodarone, the experimental group was treated with Amiodarone combined with Metoprolol. The therapeutic effects between the two groups were compared. Results The total effective rate of treatment in the experimental group was 93.0%, which was significantly higher than 76.7% in the control group, the difference was statistically significant（P0.05）. The QT interval dispersion（QTd） and heart rate were significantly lower than those before treatment in the two groups, and the QTd and heart rate of the experimental group were significantly lower than those in the control group, the differences were statistically significant（P0.05）. The incidence of adverse reactions in the experimental group was 9.3%, that in the control group was 27.9%, and the incidence of adverse reactions in the experimental group was significantly lower than that of the control group, the difference was statistically significant（P0.05）. Conclusion The treatment of Amiodarone combined with Metoprolol in the elderly patients with coronary heart disease complicated with arrhythmia can achieve ideal therapeutic effect, with less adverse reactions, high safety and reliability, can improve the symptoms of the patients significantly, and control the heart rate reasonably. It is worth popularizing in clinical practice.