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活络通痹汤足浴联合前列地尔治疗糖尿病周围神经病变疗效及对氧化应激指标、胱抑素C水平的影响 被引量:14

Effect of Huoluo Tongbi Decoction combined with prostaglandin on diabetic peripheral neuropathy and its effect on oxidative stress and Cystatin C
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摘要 目的观察活络通痹汤足浴联合前列地尔治疗糖尿病周围神经病变疗效及对患者氧化应激指标、胱抑素C(Cys C)水平的影响。方法将100例糖尿病周围神经病变患者随机分为2组,2组均给予常规对症干预,包括饮食控制、运动干预、胰岛素注射等,同时给予甲钴胺口服。在此基础上,对照组50例给予前列地尔治疗,观察组50例在对照组治疗基础上给予活络通痹汤足浴,2组治疗时间均为4周。观察2组治疗前后主要证候积分、神经运动传导速度(MNCV)、神经感觉传导速度(SNCV)、总抗氧化能力(TAOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)及Cys C水平变化,统计2组临床疗效和不良反应发生情况。结果治疗后,2组肢体麻木或不温、肢体疼痛、气短乏力、自汗畏风、五心烦热、口干少饮积分和MDA、Cys C水平均显著降低(P均<0.05),且观察组均显著低于对照组(P均<0.05);2组MNCV、SNCV、TAOC及SOD水平均显著提高(P均<0.05),且观察组均显著高于对照组(P均<0.05)。观察组临床治疗总有效率显著高于对照组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论活络通痹汤足浴联合前列地尔治疗糖尿病周围神经病变可有效缓解临床症状体征,加快神经传导速度,调节氧化应激指标和Cys C水平,且安全性好。 Objective It is to observe the effect of Huoluo Tongbi Decoction combined with alprostadil on diabetic peripheral neuropathy and its effect on the indexes of oxidative stress and level of Cystatin C( Cys C). Methods 100 patients with diabetic peripheral neuropathy were randomly divided into two groups. Both groups received routine symptomatic intervention,including diet control,exercise intervention,oral hypoglycemic or insulin injection,and oral administration of mecobalamin. On the basis of above treatment,50 patients in the control group were treated with alprostadil,and 50 patients in the observation group were given the foot bath of Huoluo Tongqiao Decoction. Both groups were treated for 4 weeks. The main syndrome scores,neuromotor conduction velocity( MNCV),neurosensory conduction velocity( SNCV),the levels of total antioxidant capacity( TAOC),superoxide dismutase( SOD),malondialdehyde( MDA) and Cys C before and after treatment were observed,the clinical efficacy was evaluated and adverse reactions were recorded in the two groups. Results After treatment,the scores of limb numb or not warm,limb pain,shortness of breath,fatigue,spontaneous sweating,five upset fever,dry mouth and low drink scores,and the levels of MDA and Cys C were significantly decreased in both groups( P〈0. 05),and the decrease in the observation group was more significant( P〈0. 05); The MNCV,SNCV,TAOC and SOD levels were significantly increased in both groups( P〈0. 05),and the increase in the observation group was more significant than the control group( P〈0. 05); The total effective rate of observation group was significantly higher than that of the control group( P〈0. 05). There was no significant difference in the incidence of adverse reactions between the two groups( P〉0. 05). Conclusion Huoluo Tongbi Decoction combined with alprostadil can effectively alleviate clinical symptoms and signs,accelerate nerve conduction velocity,regulate oxidative stress index and Cys C level,and be safe in the treatment of diabetic peripheral neuropathy.
作者 李建树 张宪美 LI Jianshu;ZHANG Xianmei(Zhaozhuang Hospital of Traditional Chinese Medicine,Zaozhuang 277100,Shandong,China)
出处 《现代中西医结合杂志》 CAS 2018年第25期2776-2779,共4页 Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词 活络通痹汤 糖尿病周围神经病变 足浴 氧化应激 胱抑素C Huoluo Tongbi Decoction diabetic peripheral neuropathy foot bath oxidative stress Cys C
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