季铵盐有机硅双子表面活性剂的物化及抗菌性能

Physicochemical and Antibacterial Properties of Quaternary Ammonium Organic Silicon Gemini Surfactants

以聚乙二醇二缩水甘油醚和不同黏度羟基封端聚二甲基硅氧烷为主要原料,在四丁基溴化铵（TBAB）和Na OH的催化下,合成出不同硅氧链长的环氧基聚醚改性硅氧烷EP-PSix-EP（x=40、80、315,下同）,EP-PSix-EP再与N,N-二甲基十二烷基叔胺在盐酸催化下进行季铵化反应,制备得到连接基长度不同的季铵盐有机硅双子表面活性剂C12-PSix-C12（x=40、80、315,下同）。采用FTIR、1HNMR对产物结构进行了表征。考察了C12-PSix-C12中连接基长度对其表面张力、润湿性能、乳化稳定性等物化性能及抗菌性能的影响。结果表明,随着C12-PSix-C12中连接基长度的减小,C12-PSix-C12的表面活性、润湿性能及抗菌能力逐渐增强。它们的γCMC依次为29.74、31.17、44.95 m N/m;在玻璃表面的最大接触角依次为48.3？、59.9？、65.6？;对金黄色葡萄球菌的抑菌圈宽度分别为38.5、34.5、27.5 mm。并且C12-PSi40-C12对液体石蜡、煤油、油酸的乳化稳定性能最好,乳化稳定时间分别为260.5、732.3、1537.0 s。

A series of epoxy-modified polyether ploysiloxanes（EP-PSix-EP, x=40,80,315） were synthesized from ployethyleneglycol diglycidyl ether and polydimethylsiloxane by using tetrabutylammonium bromide（TBAB） and Na OH as catalyst. Then, corresponding quaternary ammonium organic silicon gemini surfactants, C12-PSix-C12（x=40,80,315,as the below）, were synthesized by quaternarization of EP-PSix-EP with N,N-dimethyldodecylamine in the presence of a catalytic amount of hydrochloric acid. The samples were characterized by FTIR and 1 HNMR. The effect of spacer length on the characteristics of quaternary ammonium organic Gemini surfactant was investigated. The results showed that the surface activity, wetting property and antimicrobial ability of surfactant gradually enhanced with the decrease of the length of spacer group in C12-PSix-C12. The surface tension values of above three surfactants at CMC（γCMC） were 29.74, 31.17 and 44.95 m N/m, respectively. The maximal contact angle values on the glass were 48.3？, 59.9？ and 65.6？. The diameter of inhibition zone of C12-PSix-C12（x =40,80,315） to Staphylococcus aureus was 38.5, 34.5 and 27.5 mm, respectively. Furthermore, C12-PSi40-C12 exhibited the best emulsion stability to liquid paraffin, kerosene and oleic acid, with corresponding emulsifying stability time of 260.5, 732.3 and 1537.0 s.