血小板参数在多发性脑梗死和肺部感染老年患者中变化分析

Analysis of the change of platelet parameters in elderly patients with multiple cerebral infarction and pulmonary infection

目的回顾性分析多发性脑梗死和肺部感染老年患者血小板参数变化情况。方法对多发性脑梗死、肺部感染老年患者分组并设立正常对照组,回顾性调查三组人群血小板数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)及血小板压积(PCT),统计分析三组间血小板参数可能存在的差异。结果血小板参数在多发性脑梗死组(n=35)分别为PLT(201.947±73.849)×109·L-1、MPV(9.269±1.143)fl、PDW(16.024±0.369)、PCT(0.184±0.059);肺部感染组(n=43)分别为PLT(222.014±115.309)×109·L-1、MPV(9.006±1.263)fl、PDW(16.082±0.579)、PCT(0.194±0.098);对照组(n=42)分别为PLT(192.719±55.335)×109·L-1、MPV(9.599±1.219)fl、PDW(16.064±0.392)、PCT(0.181±0.041)。MPV和PLT在三组间差异有统计学意义:多发性脑梗死组和肺部感染组MPV均明显低于对照组MPV(P=0.019;P=0.000);肺部感染组PLT明显高于对照组PLT(P=0.003)。PDW(F=0.616,P=0.541)和PCT(F=1.376,P=0.254)在三组间差异无统计学意义。结论 MPV和PLT的改变可能和老年患者多发性脑梗死及肺部感染发病相关,可作为一个潜在的诊疗指标。

Objective To analyze the change of platelet parameters in the elderly patients with multiple cerebral infarction and pulmonary infection retrospectively. Methods To allocate the elderly patients to multiple cerebral infarction group,pulmonary infection group and control group randomly,the platelet count PLT（× 109·L-1）,mean platelet volume MPV（fl） and platelet distribution width PDW,platelet crit PCT among 3 groups were investigated retrospectively and the differences of parameters among 3 groups were analyzed statistically. Results In multiple cerebral infarction group,the related date were： PLT（201. 947 ± 73. 849） × 109·L-1,MPV（9. 269 ± 1. 143） fl,PDW（16. 024 ± 0. 369） and PCT（0. 184 ± 0. 059）（n = 35）. In pulmonary infection group were PLT（222. 014 ±115. 309） × 109·L-1,MPV（9. 006 ± 1. 263） fl,PDW（16. 082 ± 0. 579） and PCT（0. 194 ± 0. 098）（n = 43） and in control group were PLT（192. 719 ± 55. 335） × 109·L-1,MPV（9. 599 ± 1. 219） fl,PDW（16. 064 ± 0. 392） and PCT（0. 181 ± 0. 041）（n = 42）.The differences of MPV and PLT among the 3 groups were significant： MPV of multiple cerebral infarction group and pulmonary infection group were significantly decreased to the control group（P = 0. 019; P = 0. 000）; PLT of pulmonary infection group were obviously increased to the control group（P = 0. 003）. PDW（F = 0. 616,P = 0. 541） and PCT（F = 1. 376,P = 0. 254） among 3 groups showed no statistical difference. Conclusion There is association of the change of PLT and MPV in elderly patients with multiple cerebral infarction and pulmonary infection and may be used as a potential indicator of diagnosis and treatment.