叶酸联合幽门螺杆菌根除治疗慢性萎缩性胃炎患者的疗效分析及安全性分析

Efficacy Analysis and Safety Analysis of Folic Acid Combined with Heli-cobacter Pylori Eradication in the Treatment of Chronic Atrophic Gastritis

目的研究叶酸联合幽门螺杆菌根除治疗慢性萎缩性胃炎患者的疗效观察及安全性。方法选择该院于2017年1月—2018年1月收治的114例慢性萎缩性胃炎患者,采用随机数字表法将患者平均分为观察组和对照组,每组57例。对照组患者采用左氧氟沙星治疗,观察组患者采用叶酸联合幽门螺杆菌根除治疗,比较两组患者的治疗效果和患者的满意程度。结果观察组患者治疗的有效率高于对照组患者,观察组患者治疗的总有效率为96.49%,对照组患者治疗的总有效率为77.19%,两组比较差异有统计学意义(χ~2=9.288 9,P=0.002 3)。对照组患者对治疗的满意程度低于观察组患者,对照组患者对治疗的满意程度为71.92%,观察组患者对治疗的满意程度为94.73%,两组比较差异有统计学意义(χ~2=10.673 7,P=0.001 0)。结论对慢性萎缩性胃炎患者采用叶酸联合幽门螺杆菌根除治疗,效果显著,具有一定的安全性,患者的满意程度更高,有利于形成良好的医患关系。

Objective To investigate the efficacy and safety of folic acid and Helicobacter pylori eradication in the treatment of chronic atrophic gastritis. Methods A total of 114 patients with chronic atrophic gastritis admitted to the hospital from January 2017 to January 2018 were randomly divided into observation group and control group by random number table method, 57 cases in each group. Patients in the control group were treated with levofloxacin. Patients in the observation group were treated with folic acid and Helicobacter pylori eradication. The treatment effect and patient satisfaction were compared between the two groups. Results The observation group was more effective than the control group. The total effective rate was 96.49% in the observation group and 77.19% in the control group. The comparison between the two groups was. The difference was statistically significant（χ^2=9.288 9, P =0.002 3）. The patients in the control group were less satisfied with the treatment than in the observation group. The patients in the control group were 71.92% satisfied with the treatment, and the patients in the observation group were 94.73% satisfied with the treatment. The comparison between the two groups presented as, with statistical significance（χ^2=10.673 7, P=0.001 0）.Conclusion The use of folate combined with H. pylori eradication therapy for patients with chronic atrophic gastritis has a significant effect, a certain degree of safety, a higher degree of patient satisfaction, and is conducive to the formation of a good doctor-patient relationship.