卡托普利舌下含服结合硝酸甘油静脉滴注治疗高血压急诊的效果研究

Effect of Captopril Sublingual Combined with Nitroglycerin Intravenous Drip in the Treatment of Hypertension Emergency

目的:对比卡托普利舌下含服结合硝酸甘油静脉滴注治疗高血压急诊的效果。方法:选取2016年3月至2017年3月在我院接受治疗的高血压急诊患者103例,采用随机数字表法将患者分为两组,即观察组(n=55)和对照组(n=48)。对照组给予硝酸甘油静脉滴注治疗,观察组给予卡托普利舌下含服+硝酸甘油静脉滴注治疗。对比患者治疗后临床效果,记录患者治疗前、治疗后舒张压、收缩压、心率变化情况,记录患者治疗后头晕耳鸣、心动过速、心率加快等不良反应发生率,比较两组患者治疗后满意率情况,比较治疗前、治疗后两组患者社会功能、心理功能、物质生活、总分等生活质量变化。结果:治疗后,观察组总有效率(94.55%)高于对照组(75.00%),差异有统计学意义(P<0.05);治疗后,两组患者舒张压、收缩压等指标均低于治疗前,差异有统计学意义(P<0.05);且观察组以上指标均低于对照组,差异有统计学意义(P<0.05);治疗后,两组患者心率指标与治疗前比较降低,差异有统计学意义(P<0.05);且观察组低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均有出现头晕耳鸣、心动过速、心率加快等不良反应,观察组发生率(7.27%)低于对照组(25.00%),差异有统计学意义(P<0.05);治疗后,观察组患者满意率为92.73%,对照组患者满意率为72.92%,观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组患者社会功能、物质生活、心理功能、总分等生活质量指标评分均高于治疗前,差异有统计学意义(P<0.05);且治疗后观察组以上生活质量指标高于对照组,差异有统计学意义(P<0.05)。结论:采用卡托普利舌下含服+硝酸甘油静脉滴注治疗高血压急症,可快速将患者血压水平降低至正常水平,改善患者心率,提高患者生活质量,降低患者不良反应发生率,提高患者满意率。

Objective ： To compare the effect of captopril sublingual combined with nitroglycerin intravenous drip in the treatment of hy-pertension emergency. Methods ：103 patients with hypertension emergency in our hospital from March 2016 to March 2017 were selected, and the patients were divided into two groups, the observation group （n = 55） and the control group （n = 48）. The control group was giv-en nitroglycerin intravenous drip, while the observation group was given eaptopril sublingual plus nitroglycerin intravenous drip. The clini-cal effect of patients after treatment was compared. The changes of diastolic pressure, systolic pressure and heart rate were recorded before and after treatment. The incidence of adverse reactions such as dizziness and tinnitus, taehyeardia and heart rate accelerated after treat-ment were recorded. The satisfaction rate of the two groups after treatment was compared, and the change social function of psychological function, material life, total score and other quality of life changes. Results：After treatment, the total effective rate of the observation group （94. 55% ） was higher than that of the control group （75.00%）. The difference was statistically significant （P 〈 0. 05 ）. After treatment, the indexes of systolic pressure and systolic pressure in the two groups were lower than those before treatment, the difference was statistically significant （ P 〈 0. 05 ）, and the above of indicators the observation group were lower than the control group, the difference was statistically significant （ P 〈 0. 05 ）. After treatment, the heart rate indexes of the two groups were lower than that before treatment, the difference was statistically significant（ P 〈 0. 05 ）, and the observation group was lower than the control group, the difference was sta-tistically signifieant（P 〈 0. 05）. During the treatment, patients in the two groups had adverse reactions such as dizziness tinnitus, taehy-eardia and heart rate quickening. The incidence of adverse reactions of observation group was 7.27% , lower than that of the control group （25.00%）. The difference between the two groups had been statistically significant（P 〈 0. 05）. After treatment, the satisfaction rate of the observation group was 92. 73% , the satisfaction rate of the patients in the control group was 72. 92% , and the observation group was higher. After treatment, the scores of the social function, material life, mental function and total score of the two groups were higher than those before treatment, and the difference was statistically significant（ P 〈 0. 05 ）, and after treatment, the quality of life in the observation group was higher than that in the control group, and the difference between the two groups was statistically significant （ P 〈 0. 05 ）. Conclusion： The use of captopril sublingual and nitroglycerin intravenous drip to treat hypertension emergency can quickly reduce the blood pressure level to the normal level, improve the patient＇s heart rate, improve the patient＇s quality of life, reduce the incidence of adverse reactions,improve the satisfaction rate of the patients.