川芎嗪注射液联合阿司匹林对妊娠期高血压疾病患者凝血指标及母婴结局的影响

Effect of ligustrazine injection combined with aspirin on blood coagulation index and maternal and infant outcome in patients with hypertensive disorder complicating pregnancy

目的探讨川芎嗪注射液联合阿司匹林对妊娠期高血压疾病患者凝血指标及母婴结局的影响。方法回顾性分析2016年4月至2017年7月成都市妇女儿童中心医院收治的妊娠期高血压疾病患者86例的临床资料,按照治疗方法分为观察组和对照组,每组43例。对照组采用阿司匹林治疗;观察组采用川芎嗪注射液联合阿司匹林治疗。检测两组治疗前后收缩压、舒张压、平均动脉压、尿蛋白定量、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)、纤维蛋白原、D-二聚体的水平,随访记录两组妊娠结局。结果观察组疗效优于对照组,差异有统计学意义(P<0.05);两组治疗后收缩压、舒张压、平均动脉压、尿蛋白定量显著降低(P<0.05),且观察组低于对照组,差异有统计学意义(P<0.05);两组治疗后APTT、PT、TT明显升高,纤维蛋白原、D-二聚体水平明显降低(P<0.05),且观察组优于对照组,差异均有统计学意义(P<0.05);观察组剖宫产、产后出血、胎盘早剥发生率低于对照组,差异均有统计学意义(P<0.05)。结论川芎嗪注射液能改善妊娠期高血压疾病患者的凝血指标及母婴结局。

Objective To investigate the effect of ligustrazine injection combined with aspirin on blood coagulation index and maternal and infant outcome in patients with hypertensive disorder complicating pregnancy（ HDCP）.Methods Clinical data of 86 patients with HDCP in Chengdu Women＇s and Children＇s Central Hospital from April 2016 to July 2017 were analyzed retrospectively and divided into the observation group and the control group.The control group was treated with aspirin.The observation group was treated with ligustrazine injection combined with aspirin.The levels of SBP,DBP,MPA,24 h Upro,APTT,PT,TT,FIB,D-Dimer were detected before and after treatment in the two groups.The pregnancy outcome of the two groups was recorded.Results The curative effect of the observation group was better than that of the control group.The difference was statistically significant（ P 0.05）.After treatment,SBP,DBP,MPA and 24 h Upro of two groups were significantly decreased（ P 0.05）.The SBP,DBP,MPA and 24 h Upro after treatment in the observation group were significantly lower than those in the control group.The difference was statistically significant（ P 0.05）.After treatment,APTT,PT and TT of two groups were significantly increased,and FIB and D-Dimer were significantly decreased（ P 0.05）.After treatment,the APTT,PT and TT of the observation group were higher than those of the control group,and the FIB and D-Dimer were lower than those of the control group.The difference was statistically significant（ P 0.05）.The cesarean section,postpartum hemorrhage and placental abruption were lower in the observation group than in the control group.The difference was statistically significant（ P 0.05）.Conclusion ligustrazine injection can improve the coagulation index and maternal outcome in patients with HDCP.