四川南充地区3762例女性高危型人乳头瘤病毒感染结果分析

Analysis of 3762 women with high-risk HPV infection in Nanchong area,Sichuan

目的分析南充地区女性高危型人乳头瘤病毒(high-risk human papillomavirus,HR-HPV)感染率、亚型及其分布特点。方法收集南充市中心医院2014年7月至2017年7月门诊及体检共3 762例女性宫颈分泌物标本。采用荧光PCR法进行15种HR-HPV分型检测,并将所有受检者分为6个年龄段,对所得结果进行分析。结果 3 762例受检者共检测出阳性659例,阳性率为17.5%,感染以单一和双重为主,检出率最高的3种亚型依次为52型209例(31.7%)、58型173例(26.3%)和16型152例(23.1%);6个年龄段中,阳性率较高的是≤20岁(19.1%)、51~60岁(22.8%)和≥61岁(29.5%)人群。结论南充地区女性HR-HPV感染以52、58、16型为主,表现出明显的地域特点。HR-HPV检测对本区域宫颈肿瘤的早期预防和筛查有指导意义。

Objective To analyze the infection rate,subtype and distribution of high-risk（ human papillomavirus（ HR-HPV）in women in Nanchong area.Methods A total of 3 762 female cervical secretion specimens were collected in Nanchong Central Hospital from July 2014 to July 2017 for outpatient and physical examination.Fifteen HR-HPV typing tests were performed by fluorescence PCR,and all subjects were divided into 6 age groups,and the results were analyzed.Results A total of 659 positive samples were detected in 3 762 subjects,the positive rate was 17.5 %.The infections were mainly single and double.The three subtypes with the highest detection rate were HPV52 209 cases（ 31.7 %） and HPV58 173 cases（ 26.3 %） and 152 cases（ 23.1 %）of type 16; Among the 6 age groups,the higher positive rate was ≤20 years old（ 19.1 %）,51 ~ 60 years old（ 22.8 %） and ≥61 years old（ 29.5 %）.Conclusion The female HR-HPV infection in Nanchong area was mainly 52,58 and 16 types,showing obvious regional feature.HR-HPV testing is instructive for early prevention and screening of cervical tumors in the region.