双草退黄汤治疗慢性重型肝炎的临床研究

Clinical Study on the Effect of Shuangcao Tuihuang Decoction in Treatment of Chronic Severe Hepatitis

目的:研究双草退黄汤治疗慢性重型病毒性肝炎的疗效并对其作用机理作初步探讨。方法:以温补脾肾、活血化瘀法为重点组成双草退黄汤,将全部48例慢重肝患者分为两组,观察组21例服用双单退黄汤,每日1剂,连服4～8周,对照组27例不服用中药,全部病例均静脉滴注TAD、HGF。结果:观察组病死率66.67％(14/21)明显低于对照组81.48％(22/27),观察组57.14％的患者消化系统功能有不同程度改善,且CD_4^+/CD_8^+比值增高而CD_8^+有所降低,可溶性白细胞介素-2受体明显升高(P<0.01)。结论:双草退黄汤可能具有改善慢重肝患者消化系统功能及调节细胞免疫的作用;对慢重肝患者有一定疗效。

Aim; To investigate the effect of Shuangcao tuihuang decoction on chronic severe hepatitis and preliminarily study its mechanism of action. Methods: Forty-eight patients with chronic severe hepatitis were randomly divided into two groups. Twenty-one patients in test group were treated with Shuangcao tuihuang decoctionon orally, once a day for 8 weeks, 27 patients in cotrol group were not given Shuangcao tuihuang decoction. All patients received TAD and HGF by intravenous drip. Results: The mortality in test group (66. 67%) was obviously lower than that in control group (81. 48%). 57. 14% of patients'digestive function in test group was improved and CD8+/CD8+ ratio and the level of the-solvable interleukin-2 receptor increased (P<0. 01). The level of the CD8+ reduced. Conclusions: All above suggest that Shuangcao tuihuang decoction could reduce the mortality for chronic severe hepatitis by improving the function of digestive system and cellular immunity.