蛛网膜下腔出血早期脑损伤后神经元细胞凋亡研究新进展

Research advance of neuronal cell apoptosis after early brain injury in subarachnoid hemorrhage

蛛网膜下腔出血(SAH)死亡和残疾的主要原因可能是早期脑损伤(EBI)和脑血管痉挛。虽然许多药物已经被用于治疗脑血管痉挛,但即使血管痉挛被逆转,其结果也没有得到改善。基于这些研究,EBI被认为是未来研究治疗SAH的一个主要目标,细胞凋亡可能参与SAH后EBI的过程。SAH后EBI作用机制包括颅内压增加、脑血流量减少、离子紊乱及细胞凋亡等,其中细胞凋亡被认为是重要的因素。本文总结了近年来关于SAH后EBI和细胞凋亡关系发表的文献,并对其重要性作一概述。

The main reasons to death and disability in subarachnoid hemorrhage（ SAH） might be early brain injury（ EBI） and Cerebral Vasospasm. Many drugs have been studied and used to treat cerebral vasospasm and it has been reversed,but the outcomes were not changed. Based on these studies,EBI is considered to be a major target in the treatment of SAH in the future,and apoptosis may be involved in the process of early brain damage after SAH. The mechanisms of EBI after SAH including intracranial pressure increase,cerebral blood flow reduction,ion disturbance and cell apoptosis with cell apoptosis being regarded as the most important factor. This article is to summarize the relationship between EBI and cell apoptosis after SAH according to recent literature,and give an overview of its importance.