脑外伤干细胞治疗进展

Research progress on stem cell therapy for traumatic brain injury

颅脑损伤(TBI)是影响人类健康及导致残疾的重要原因,可引起严重的神经功能损伤。目前,临床上对于脑外伤后神经功能障碍的治疗方法主要有高压氧、脑刺激及行为治疗等,但治疗效果有限。而最近的研究发现外源性干细胞可迁移至受损脑组织,然后通过进一步分化从而替换受损细胞、释放抗炎症因子及生长因子等途径参与损伤脑组织的修复,显著改善神经功能。本文主要将对不同类型的干细胞治疗TBI效果、不足之处及相关机制进行综述。

Traumatic brain injury（ TBI） is one of the leading causes of disability,affecting people＇s health,and causing major neurological injury. Various therapeutic strategies are available for TBI,including hyperbaric oxygen therapy,noninvasive brain stimulation and behavioral therapies. However,the therapeutic effect is still limited. In recent years,a large number of studies have found that exogenous stem cells can migrate to damaged brain tissue and participate in the repair of damaged brain tissue,which significantly improve nerve function by replacing damaged cells,as well as releasing anti-inflammatory factors and growth factors. This review will summarize the advantages,disadvantages,mechanisms and the future of stem cell therapy for TBI.