激光散斑对比成像技术在疤痕疙瘩激光治疗中的应用研究

Application Study of Laser Speckle Contrast Imaging in the Treatment of Keloid

目的探讨激光散斑对比成像技术(Laser speckle contrast imaging,LSCI)在疤痕疙瘩激光治疗前后血流变化的监测作用。方法 20例疤痕疙瘩患者接受585 nm脉冲染料激光治疗前后分别接受LSCI照射,建立治疗前后疤痕疙瘩相对血流散斑流速指数(Speckle flow index,ΔSFI),比较ΔΔSFI与临床评分温哥华疤痕量表(Vancouver scar scale,ΔVSS)之间的联系。结果 20例患者治疗前VSS评分为8.20±2.93,治疗后VSS评分为6.45±2.19(P<0.05);治疗前ΔSFI为1.77±0.54;治疗后ΔSFI为1.43±0.41(P<0.05),ΔVSS与ΔΔSFI正相关(r=0.539,P=0.014 2)。结论 LSCI可客观量化的监测疤痕疙瘩治疗前后微循环血流变化,为评估疤痕疙瘩严重程度及治疗效果上提供了一种新的方法。

Objective In order to investigate the effects of laser speckle contrast imaging in blood flow change of keloid pre and post-laser treatment. Methods Twenty keloid patients were graded by vancouver scar scale VSS and detected by laser speckle contrast imaging LSCI to monitor the blood flow in lesion before and after 585 nm pulsed dye laser treatment.Evaluate the relationship between the SFI and VSS of the lesion. Results The VSS score of patients pre-and post-treatment were （8.20±2.93） and （6.45±2.19） respectively （P〈0.05） . While the SFI of patients pre- and post-treatmentwere （1.77±0.54） and （1.43±0.41） respectively （P〈0.05） . There was a moderate positive correlation relationship between the grade of severity evaluated by VSS and the blood flow change detected by LSCI（r=0.539 P=0.0142） . Conclusion LSCI can assess keloid severity objectively and quantifiably. LSPI is a new measure method to evaluate the lesion severity of keloid and assess the therapeutic effects.