脾氨肽联合激光对尖锐湿疣患者淋巴细胞和细胞因子水平的影响

Effect of Spleen Peptide Combined with Laser on Lymphocyte and Cytokine Levels in Patients with Condyloma

目的探讨脾氨肽联合激光对尖锐湿疣患者的临床效果及对患因子水平的影响者淋巴细胞和细胞因子水平的影响。方法选择2012年1月—2015年1月本院皮肤性病门诊收治的98例尖锐湿疣患者进行研究,采用随机数字表法分为联合组和对照组各49例,联合组采用脾氨肽联合激光治疗,对照组仅采取激光治疗,对比2组患者的临床效果、T淋巴细胞亚群及细胞因子水平差异。结果治疗前,联合组和对照组的T淋巴细胞亚群值、白介素细胞(IL)-2、IL-10水平差异均无统计学意义(P>0.05);治疗后,联合组患者的CD3^+、CD4^+、CD4^+/CD8^+值、IL-2水平均显著的高于对照组患者(P<0.05),联合组的CD8^+值、IL-10水平显著的低于对照组患者(P<0.05);治疗后2组患者的CD3^+、CD4^+、CD4^+/CD8^+值、IL-2水平较治疗前均显著的提高(P<0.05),CD8^+、IL-10水平较治疗前均显著的降低(P<0.05);联合组的痊愈率89.80%显著的高于对照组的73.47%(P<0.05);联合组的远期复发率6.12%显著的低于对照组的20.41%(P<0.05)。结论脾氨肽联合激光对尖锐湿疣患者具有较好的临床效果,其作用机制与改善患者的免疫水平有关。

Objective In order to investigate the clinical effect of the spleen and ammonia peptide combined with laser on the level of lymphocyte and cytokine in patients with condyloma. Methods A total of 98 patients with condyloma acuminatum treated in our hospital dermatology clinic from January 2012 to January 2015 were selected for study. Patients were randomly divided into the combined group and the control group with 49 cases in every group,the combination group with spleen ammonia peptide combined with laser treatment,the control group only to laser treatment,The clinical effects,T lymphocyte subsets and cytokine levels in two groups were compared. Results Before treatment,there was no significant difference in T lymphocyte subsets,IL-2 and IL-10 between the two groups （P〉 0.05）. After treatment,the levels of CD3＋、CD4＋、CD4＋/CD8＋and IL-2 in the combined group were significantly higher than those in the control group （P〈0.05）. The CD8＋ and IL-10 levels in the combined group were significantly lower than those in the control group Patients （P〈0.05）. After treatment,the levels of CD3＋、CD4＋、CD4＋/CD8＋ and IL-2 in both groups were significantly increased （P〈0.05）,and the levels of CD8＋ and IL-10 were significantly lower than those before treatment）. The cure rate of the combination group was 89.80%,which was significantly higher than that of the control group （73.47%,P 〈0.05）. The long -term recurrence rate was 6.12% in the combined group was significantly lower than that of the control group 20.41% （P〈0.05）. Conclusion Spleen aminopeptidase combined laser on patients with genital warts have better clinical results,its mechanism and improve immunity patients.