不同期别子宫内膜异位症对卵巢储备功能的影响

The Effect of Different Stages Endometriosis on Ovarian Reserve

目的通过检测血清抗苗勒管激素(AMH)水平以探讨不同期别子宫内膜异位症对卵巢储备功能的影响。方法收集我院2016年1月—2018年4月收治的子宫内膜异位症患者80例作为观察组,其中轻中度组(Ⅰ~Ⅱ期)40例,重度组(Ⅲ~Ⅳ期)40例;同期非子宫内膜异位症单纯行卵巢畸胎瘤剥除术或子宫肌瘤剔除术的患者44例作为对照组,获取术前血清AMH检测值及临床资料。AMH测定采用酶联免疫吸附试验,对3组结果进行比较。结果对照组患者的AMH(6.90±0.56)μg/L,高于轻中度组的(5.15±0.59)μg/L和重度组患者的(2.86±0.23)μg/L,三组比较差异具有统计学意义,P<0.05。结论针对不同程度子宫内膜异位症患者血清AMH水平的测定和比较,可以看出血清AMH水平可以作为评估子宫内膜异位症病变严重程度的指标。

Objective To measure AMH serum levels in order to demonstrate the effect of different stages endometriosis on ovarian reserve.Methods 80 cases of endometriosis admitted to our hospital from January 2016 to April 2018 were selected as the observation group.40 cases in mild and moderate group（Ⅰ to Ⅱ）,40 cases in severe group（Ⅲ to Ⅳ stage）.In the same period,44 patients with non endometriosis treated with ovarian teratoma or myomectomy were selected as the control group,and the preoperative serum AMH and clinical data were obtained.AMH was determined by enzyme-linked immunosorbent assay（ELISA）,and the results of three groups were compared.Results The level of AMH was（6.90±0.56） μg/L in the control group,which was higher than（5.15±0.59） μg/L in the mild to moderate group and（2.86±0.23） μg/L in the severe group.The difference among the three groups was statistically significant,P〈 0.05.Conclusion From the comparison of serum AMH levels of different stages EMS with the control group,we can see that AMH could be used to access the seriousness of EMS.