摘要
目的分析子宫颈疾病筛查中检测高危型人乳头瘤病毒(HRHPV)的临床意义。方法我院2015年4月—2018年6月联合液基细胞学(TCT)与HR-HPV检测者414例,其中384例细胞学正常但HR-HPV检测阳性或细胞学正常、HR-HPV检测阴性但高度怀疑病变患者结合病理结果进行分析。结果 TCT联合HR-HPV检测的414例患者中,TCT正常或炎症、ASC-H和ASC-US、LSIL、HSIL的HR-HPV阳性率分别为22.4%、47.2%、71.8%、88.9%,随着细胞学诊断级别的升高,HR-HPV阳性率显著上升(P<0.05)。结合病理诊断的384例患者中,正常或炎症、CIN1、CIN2、CIN3、SCC、湿疣的HPV-DNA阳性率分别为21.3%、83.3%、86.1%、87.5%、91.7%、72.5%,与正常或炎症比较差异具有统计学意义(P<0.05)。结论随着细胞学形态异型病变级别的升高,HR-HPV阳性率逐渐上升,其与宫颈病变的演进密切相关,用于子宫颈癌筛查对疾病诊断和预后评估有一定的临床意义。
Objective To analyze the clinical significance of detecting high-risk human papillomavirus in cervical disease screening. Methods In our hospital, 414 patients from April 2015 to June 2018 were combined with liquid-based cytology (TCT) and HR-HPV, of which 384 were normal cytology but positive for HR-HPV or normal for cytology and negative for HR-HPV. However, highly suspected patients with pathology were analyzed for pathological fndings. Results The HR-HPV positive rates of TCT normal or infammation, ASC-H and ASC-US, LSIL, and HSIL were 22.4%, 47.2%, 71.8%, and 88.9%, respectively, in 414 patients with TCT and HR-HPV. The cytological diagnosis level increased, and the HR-HPV positive rate increased signifcantly (P 〈 0.05). Among the 384 patients with pathological diagnosis, the positive rates of HPV-DNA in normal or inflammation, CIN1, CIN2, CIN3, SCC, and genital warts were 21.3%, 83.3%, 86.1%, 87.5%, 91.7%, and 72.5%, respectively. Or infammation was statistically diferent (P 〈 0.05). Conclusion With the increase of cytological morphological grades, the positive rate of HR-HPV gradually increases, which is closely related to the evolution of cervical lesions. The screening for cervical cancer has certain clinical signifcance for disease diagnosis and prognosis evaluation.
作者
刘海霞
司百会
吴建龙
杜薇
尹国玉
LIU Haixia;SI Baihui;WU Jianlong;DU Wei;YIN Guoyu(Department of Gynecology,Chengde Central Hospital,Chengde Hebei 067000,China;Department of Pathology;Department of Ultrasound;Department of Oncology Surgery)
出处
《中国继续医学教育》
2018年第25期72-73,共2页
China Continuing Medical Education
关键词
子宫颈筛查
人乳头瘤病毒
液基薄层细胞学检测
阴道镜活检
宫颈电圈切除术
子宫颈癌
cervical screening
human papillomavirus
liquid based cytology test
colposcopy biopsy
cervical loop electrosurgical excision procedure
cervical cancer