妊娠早期先兆流产患者生殖激素、血栓前状态标志物及凝血相关因子水平检测及意义

Detection and significance of reproductive hormones,prethrombotic state markers and coagulation related factors in threatened abortion in early pregnancy

目的:探讨妊娠早期先兆流产患者生殖激素、血栓前状态标志物及凝血相关因子水平变化及意义。方法:回顾我院收治的妊娠早期先兆流产患者(包括继续妊娠者和流产者)及正常妊娠早期女性的临床资料,比较3组受试者生殖激素、血栓前状态标志物及凝血相关因子水平。结果:单因素方差结果表明,组间人绒毛膜促性腺激素(β-HCG)、孕酮、雌二醇(E2)、蛋白C(PC)、纤溶酶原(PLG)、D-二聚体(D-D)、TAT、F1+2及PAI-1水平比较均具有统计学意义(P<0.05);与对照组相比,妊娠维持组与中断妊娠组β-HCG、孕酮、E2、PLG水平均显著降低(P<0.05),且中断妊娠组水平显著低于妊娠维持组(P<0.05);妊娠维持组与中断妊娠组PC、D-D、TAT、F1+2及PAI-1水平均显著高于对照组,且中断妊娠组水平显著高于妊娠维持组(P<0.05);组间ATⅢ水平差异无统计学意义(P>0.05)。结论:妊娠早期先兆流产患者存在显著的生殖激素、血栓前状态标志物及凝血相关因子水平异常,其指标水平检测对预测早期先兆流产具有重要价值。

Objective：To investigate the changes and significance of reproductive hormones,prethrombotic state markers and coagulation related factors in threatened abortion in early pregnancy.Methods：The clinical data of early pregnant miscarriage and pregnant women in the early pregnancy were reviewed in our hospital,and the levels of reproductive hormones,prethrombotic state markers and blood clotting related factors were compared between the three groups.Results：The results of single factor variance showed that the levels ofβ-HCG,progesterone,E2,PC,PLG,D-D,TAT,F1＋2 and PAI-1 were all statistically significant（P〈0.05）.Compared with the control group,the average levels ofβ-HCG,progesterone,E2 and PLG in the pregnancy maintenance group and the interrupted pregnancy group were significantly lower（P〈0.05）,and the level of the interrupted pregnancy group was significantly lower than that of the pregnancy maintenance group（P〈0.05）.The levels of PC,D-D,TAT,F1＋2 and PAI-1 in the pregnancy maintenance group and the interrupted pregnancy group were significantly higher than those in the control group,and the level of the interrupted pregnancy group was significantly higher than that of the pregnancy maintenance group（P〈0.05）.There was no significant difference in the level of AT III between the groups（P〈0.05）.Conclusion：There are significant abnormal levels of reproductive hormones,prethrombotic state markers and coagulation related factors in patients with threatened abortion in early pregnancy,the detection of its index level is of great value in predicting threatened abortion in the early stage.