甲状腺良恶性结节病理特征与超声弹性成像参数的相关性分析

Correlation of pathological features of benign and malignant thyroid nodules with ultrasonic elastography parameters

目的:探讨甲状腺良恶性结节病理特征与超声弹性成像参数的相关性。方法:选择2016年9月~2018年2月在本院接受甲状腺肿瘤切除治疗的甲状腺肿瘤患者176例作为研究对象,其中甲状腺癌患者119例作为甲状腺癌组、甲状腺腺瘤患者57例作为甲状腺腺瘤组。对比两组肿瘤组织中甲状腺癌相关增殖基因、甲状腺癌相关侵袭基因表达量以及超声弹性比值,采用Pearson检验评估上述恶性分子表达量与超声弹性比值的相关性。结果:甲状腺癌组病灶组织中甲状腺癌相关增殖基因FOXA1、YAP、TPX2mRNA的表达量高于甲状腺腺瘤组,EGCG、PDCD4mRNA的表达量低于甲状腺腺瘤组;甲状腺癌相关侵袭基因BRD4、Twist1、FoxM1、SIRT1mRNA的表达量高于甲状腺腺瘤组,Wortmannin、HIC1mRNA的表达量低于甲状腺腺瘤组;超声弹性比值水平高于甲状腺腺瘤组(P<0.05)。Pearson检验发现,甲状腺癌肿瘤组织中增殖基因、侵袭基因表达量与超声弹性比值水平直接相关。结论:甲状腺癌相关增殖基因、侵袭基因表达量与超声弹性比值水平间存在直接相关关系,超声弹性成像手段可作为判断甲状腺结节良恶性的可靠手段。

Objective：To investigate the correlation of the pathological features of benign and malignant thyroid nodules with ultrasonic elastography parameters.Methods：A total of 176 patients with thyroid tumor who underwent thyroid tumor resection in this hospital between September 2016 and February 2018 were chosen as the research subjects,among which,119 patients with thyroid cancer were selected as thyroid cancer group and 57 patients with thyroid adenoma were selected as thyroid adenoma group.The thyroid cancer-related proliferation gene and thyroid cancer-related invasion gene expression as well as ultrasonic strain ratio in tumor tissues were compared between the two groups,and Pearson test was used to evaluate the correlation between above malignant molecule expression and ultrasonic strain ratio.Results：Thyroid cancer-related proliferation genes FOXA1,YAP and TPX2 mRNA expression in lesion tissues of thyroid cancer group were higher than those of thyroid adenoma group whereas EGCG and PDCD4 mRNA expression were lower than those of thyroid adenoma group;thyroid cancer-related invasion genes BRD4,Twist1,FoxM1 and SIRT1 expression were higher than those of thyroid adenoma group whereas Wortmannin and HIC1 mRNA expression were lower than those of thyroid adenoma group;ultrasonic strain ratio was higher than that of thyroid adenoma group（P〈0.05）.The Pearson test showed that the proliferation gene and invasion gene expression in thyroid cancer tissues were directly correlated with the ultrasonic strain ratio level.Conclusion：Thyroid cancer-related proliferation gene and invasion gene expression are directly correlated with ultrasonic strain ratio level,and ultrasonic elastography can be the reliable means to judge benign and malignant thyroid nodules.