偏头痛患者采用氟桂利嗪与尼莫地平联合治疗临床观察

Clinical Observation of the Combined use of Flunarizine and Nimodipine in Patients with Migraine

目的:观察偏头痛患者采用氟桂利嗪与尼莫地平联合治疗的临床效果。方法:将在本院接受治疗的80例偏头痛患者作为研究对象,按照就诊时间分为两组,并分别给予不同治疗方案,2015年5月—2016年7月期间收治的40例患者作为对照组,给予氟桂利嗪单独治疗,2016年8月—2017年8月期间收治的40例患者作为研究组,给予氟桂利嗪与尼莫地平联合治疗。比较两组患者治疗效果。结果:治疗前两组患者头痛评分无明显差异(P>0.05);治疗后,研究组患者头痛评分明显低于对照组(P<0.05);两组患者治疗前头痛发作次数、持续时间以及伴随症状无明显差异(P>0.05);治疗后两组患者头痛发作次数、持续时间以及伴随症状均明显得到改善(P<0.05);且研究组头痛发作次数、持续时间以及伴随症状明显优于对照组(P<0.05);研究组患者躯体疼痛、情感职能、精神健康、生理功能以及总体健康评分均明显优于对照组(P<0.05);研究组患者总有效率为95.00%,对照组患者总有效率为75.00%,研究组总有效率明显优于对照组(P<0.05)。结论:为偏头痛患者使用氟桂利嗪联合尼莫地平治疗效果显著,可有效改善患者头痛症状,提高患者生活质量,值得临床推广使用。

Objective： To observe the clinical effect of funarizine combined with nimodipine in migraine patients. Methods： Eighty patients withmigraine in our hospital were divided into two groups according to the time of treatment, and were treated with different treatment schemes. 40patients were treated with funarizine alone as control group from May 2015 to July 2017., 40 patients were treated with funarizine combined withnimodipine from August 2017 to August 2018 as study group. The therapeutic effect between the two groups was compared. Results： There was nosignifcant difference on the score of headache in two groups before treatment （P〉0.05）; after treatment, the headache score of the patients in the studygroup was signifcantly lower than that in the control group （P〈0.05）; there was no signifcant difference in the number, duration and accompanyingsymptoms of headache attack between the two groups before treatment （P〉0.05）; after treatment, the number of headache attacks in the two groupswas lower than that in the control group （P〈0.05）. The duration and associated symptoms were signifcantly improved （P〈0.05）, and the number,duration and accompanying symptoms of headache in the study group were signifcantly better than those in the control group （P〈0.05）. Physiologicalfunction and overall health score were signifcantly better in the study group than those of the control group （P〈0.05）. The total effective rate was95.00 in the study group and 75.00 in the control group. The total effective rate in the study group was signifcantly better than that in the controlgroup （P〈0.05）. Conclusion： Flunarizine combined with nimodipine is effective in the treatment of migraine, which can effectively improve theheadache symptoms and improve the quality of life of the patients.